Key mutations in the spike protein of SARS‐CoV‐2 affecting neutralization resistance and viral internalization
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28407
Abstract: To control the ongoing COVID‐19 pandemic, a variety of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines have been developed. However, the rapid mutations of SARS‐CoV‐2 spike (S) protein may reduce the protective efficacy of… read more here.
Keywords: neutralization; key mutations; protective efficacy; spike protein ... See more keywords
Reducing Viral Inhibition of Host Cellular Apoptosis Strengthens the Immunogenicity and Protective Efficacy of an Attenuated HSV-1 Strain
Sign Up to like & getrecommendations! Published in 2019 at "Virologica Sinica"
DOI: 10.1007/s12250-019-00156-7
Abstract: Herpes simplex virus 1 (HSV-1), a member of α herpesviruses, shows a high infectivity rate of 30%–60% in populations of various ages. Some herpes simplex (HSV) vaccine candidates evaluated during the past 20 years have… read more here.
Keywords: hsv; cellular apoptosis; hsv strain; protective efficacy ... See more keywords
Use Chou's 5-steps rule to evaluate protective efficacy induced by antigenic proteins of Mycobacterium tuberculosis encapsulated in chitosan nanoparticles.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117961
Abstract: The study focuses on whether antigenic proteins encapsulated in biopolymeric nanoparticles can augment protective efficacy. Chitosan nanoparticles (ChN) were prepared by ionic gelation method and Culture Filtrate Proteins (CFP) - CFP-10 and CFP-21 of Mycobacterium… read more here.
Keywords: chn cfp; antigenic proteins; cfp; protective efficacy ... See more keywords
Evaluation of the protective efficacy of recombinant protective antigen vaccine (GC1109)-immunized human sera using passive immunization in a mouse model.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.12.048
Abstract: The protective efficacy of human sera from vaccinated individuals with a new recombinant protective antigen anthrax vaccine (GC1109) against lethal spore challenge was evaluated in a mouse model. Eighteen human sera were selected from the… read more here.
Keywords: gc1109; protective efficacy; human sera; vaccine ... See more keywords
Protective efficacy of peptides from Plasmodium vivax circumsporozoite protein
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.03.063
Abstract: Highlights • Short repeat-region peptides from PvCSP on a VLP protect against malaria.• The AGDR tetramer from PvCSP VK210 can, on a VLP, also protect against malaria.• Full-length PvCSP is much less protective as a… read more here.
Keywords: circumsporozoite protein; peptides plasmodium; protective efficacy; efficacy peptides ... See more keywords
Immunogenicity and protective efficacy of inactivated equine influenza (H3N8) virus vaccine in murine model.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2017.08.013
Abstract: Equine influenza viruses (EIVs) are responsible for acute contagious respiratory infection in equines and the disease remains a major threat for equine population throughout the world despite vaccination strategies in place. The present study was… read more here.
Keywords: protective efficacy; model; h3n8 virus; vaccine ... See more keywords
Protective Efficacy of Candidate Vaccines Prior to Human Clinical Trials.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.08.005
Abstract: Immunization of animals is one of the key standards for evaluation of vaccine efficacy prior to human clinical trials. However, vaccine organizations should not over-interpret these results as protective efficacy in animals may not be… read more here.
Keywords: prior human; efficacy candidate; human clinical; protective efficacy ... See more keywords
Systemic Homologous Neutralizing Antibodies Are Inadequate for the Evaluation of Vaccine Protective Efficacy against Coinfection by High Virulent PEDV and PRRSV
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02574-21
Abstract: Porcine epidemic diarrhea virus (PEDV) and porcine reproductive and respiratory syndrome virus (PRRSV) coinfection occurs commonly and can synergistically reduce feed intake and pig growth. Vaccination is an effective strategy utilized for PED and PRRS… read more here.
Keywords: coinfection; pedv prrsv; protective efficacy; ped prrs ... See more keywords
Protective efficacy of an attenuated Mtb ΔLprG vaccine in mice
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DOI: 10.1371/journal.ppat.1009096
Abstract: Bacille Calmette-Guerin (BCG), an attenuated whole cell vaccine based on Mycobacterium bovis, is the only licensed vaccine against Mycobacterium tuberculosis (Mtb), but its efficacy is suboptimal and it fails to protect against pulmonary tuberculosis. We… read more here.
Keywords: lprg vaccine; protective efficacy; mtb; efficacy ... See more keywords
Live-attenuated auxotrophic mutant of Salmonella Typhimurium expressing immunogenic HA1 protein enhances immunity and protective efficacy against H1N1 influenza virus infection.
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DOI: 10.2217/fmb-2016-0190
Abstract: AIM To evaluate the efficacy of attenuated Salmonella Typhimurium (JOL912) as a live bacterial vaccine vector. MATERIALS & METHODS The JOL912 engineered to deliver HA1 protein from influenza A/Puerto Rico/8/1934 (H1N1; PR8) virus was coined… read more here.
Keywords: ha1; protective efficacy; salmonella typhimurium; ha1 protein ... See more keywords
Designing Adjuvant Formulations to Promote Immunogenicity and Protective Efficacy of Leptospira Immunoglobulin-Like Protein A Subunit Vaccine
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DOI: 10.3389/fcimb.2022.918629
Abstract: The leptospirosis burden on humans, especially in high-risk occupational groups and livestock, leads to public health and economic problems. Leptospirosis subunit vaccines have been under development and require further improvement to provide complete protection. Adjuvants… read more here.
Keywords: immunogenicity protective; efficacy; protective efficacy; saponin ... See more keywords