Protective immunity against tuberculosis: what does it look like and how do we find it?
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Immunology"
DOI: 10.1016/j.coi.2017.08.001
Abstract: Highlights • An absence of immune correlates of protection is a barrier to vaccine development.• The immune mechanisms behind tuberculosis progression are not understood.• Fluorescent Mtb reporter strains identify permissive and controller host cells.• Bacterial… read more here.
Keywords: protective immunity; like find; look like; tuberculosis ... See more keywords
The potential significance of high avidity immunoglobulin G (IgG) for protective immunity towards SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2021.01.061
Abstract: Background Avidity is defined as the strength of binding between IgG and its specific target epitope. IgG of high avidity is established during affinity maturation. A failure to achieve high avidity IgG may result in… read more here.
Keywords: avidity; towards sars; high avidity; sars cov ... See more keywords
Fungal Polysaccharides Promote Protective Immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in microbiology"
DOI: 10.1016/j.tim.2021.02.004
Abstract: Fungal pathogens represent a rising threat against immunocompromised patients. By using Aspergillus fumigatus, Briard et al. showed that the cell wall galactosaminogalactan (GAG) triggers macrophage inflammasome activation, promoting protective immunity. This provides new insights into… read more here.
Keywords: promote protective; immunity; protective immunity; fungal polysaccharides ... See more keywords
Recombinant BCG::Rv2645 elicits enhanced protective immunity compared to BCG in vivo with induced ISGylation-related genes and Th1 and Th17 responses.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.04.025
Abstract: There is a need to develop protective vaccines against tuberculosis (TB). Recently, we identified an immunodominant T-cell antigen, Rv2645, from the region of deletion 13 (RD13) of M. tuberculosis (M. tb) H37Rv, which is absent… read more here.
Keywords: enhanced protective; rv2645; th1 th17; related genes ... See more keywords
Th1 cytokines, true functional signatures for protective immunity against TB?
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Immunology"
DOI: 10.1038/cmi.2017.113
Abstract: The lack of an effective preventative vaccine against tuberculosis (TB) presents a great challenge to TB control. Since it takes an extremely long time to accurately determine the protective efficacy of TB vaccines, there is… read more here.
Keywords: functional signatures; vaccine; signatures protective; th1 cytokines ... See more keywords
Targets of complement-fixing antibodies in protective immunity against malaria in children
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08528-z
Abstract: Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication in naturally-acquired and vaccine-induced immunity; however, specific targets of these functional antibodies and their importance in protective immunity are unknown. Among malaria-exposed individuals, we… read more here.
Keywords: complement fixing; targets complement; fixing antibodies; antibodies protective ... See more keywords
Antibodies against a β-glucan-protein complex of Candida albicans and its potential as indicator of protective immunity in candidemic patients
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02977-6
Abstract: Sera from candidemic and non-candidemic subjects were examined for antibodies against the cell wall β1,3- and β1,6-glucans, as well as the β-glucan-associated protein MP65 of Candida species. Although antibodies against each of the above components… read more here.
Keywords: protein; mp65; candidemic patients; candida ... See more keywords
Bioengineered polyester beads co-displaying protein and carbohydrate-based antigens induce protective immunity against bacterial infection
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20205-7
Abstract: The efficacy of protein and carbohydrate antigens as vaccines can be improved via particulate delivery strategies. Here, protein and carbohydrate antigens used in formulations of vaccines against Neisseria menigitidis were displayed on in vivo assembled… read more here.
Keywords: protein carbohydrate; protective immunity; polyester beads; beads displaying ... See more keywords
Reverse immunodynamics: a new method for identifying targets of protective immunity
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-37288-x
Abstract: Despite a dramatic increase in our ability to catalogue variation among pathogen genomes, we have made far fewer advances in using this information to identify targets of protective immunity. Epidemiological models predict that strong immune… read more here.
Keywords: reverse immunodynamics; immunity; immunodynamics new; method ... See more keywords
Development of a recombinant vaccine against human onchocerciasis.
Sign Up to like & getrecommendations! Published in 2021 at "Expert review of vaccines"
DOI: 10.1080/14760584.2021.1977125
Abstract: IntroductionHuman onchocerciasis caused by the filarial nematode parasite Onchocerca volvulus remains a major cause of debilitating disease infecting millions primarily in Sub-Saharan Africa. The development of a prophylactic vaccine, along with mass drug administration, would… read more here.
Keywords: vaccine; development recombinant; protective immunity; onchocerciasis ... See more keywords
Trichinella spiralis-derived extracellular vesicles induce a protective immunity against larval challenge in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens and disease"
DOI: 10.1093/femspd/ftac040
Abstract: Human trichinellosis is a serious disease with no effective treatment till now. Recently, the protective immunity induced by parasite-derived extracellular vesicles (EVs) are studied for some parasites such as Echinostoma caproni. The current study aimed… read more here.
Keywords: evs group; protective immunity; spiralis derived; derived extracellular ... See more keywords