GPR146 inhibition protects against atherosclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-019-00204-7
Abstract: Human genetic studies have established the orphan G proteincoupled receptor gene, GPR146, as a regulator of plasma cholesterol levels. In line with these findings, Yu et al. report that depletion of GPR146 in mice substantially… read more here.
Keywords: inhibition protects; gpr146 inhibition; atherosclerosis; protects atherosclerosis ... See more keywords
Chaperone-mediated autophagy protects against atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2096397
Abstract: ABSTRACT Atherosclerosis, the leading cause of cardiovascular death, is driven by hyperlipidemia, inflammation and aggravated by aging. As chaperone-mediated autophagy (CMA), a selective type of lysosomal degradation for intracellular proteins, diminishes with age and is… read more here.
Keywords: cma; protects atherosclerosis; autophagy protects; mediated autophagy ... See more keywords
Transgenic Overexpression of IL-37 Protects Against Atherosclerosis and Strengthens Plaque Stability
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000487344
Abstract: Background/Aims: Recently, studies have shown that interleukin-37 (IL-37) is involved in atherosclerosis-related diseases. However, the regulatory mechanisms of IL-37 in atherosclerosis remain unknown. This study aims to determine the role of IL-37 in atherosclerosis and… read more here.
Keywords: transgenic overexpression; overexpression protects; plaque stability; protects atherosclerosis ... See more keywords