Zinc protects chondrocytes from monosodium iodoacetate-induced damage by enhancing ATP and mitophagy.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.066
Abstract: Osteoarthritis (OA) is characterized with articular cartilage degradation, and monosodium iodoacetate (MIA)-treated chondrocyte is the most commonly used model for mimicking OA progression. Zinc protects chondrocytes from MIA-induced damage. Here, we explored the protective effects… read more here.
Keywords: zinc protects; monosodium iodoacetate; mia; protects chondrocytes ... See more keywords
Luteolin Protects Chondrocytes from H2O2-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating AMPK-Nrf2 Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5635797
Abstract: Osteoarthritis (OA) is a chronic degenerative disease featured by cartilage erosion and inflammation. Luteolin, a member of the flavonoid family, has been shown to exert anti-inflammatory and antioxidative activities. However, the potential biological effects and… read more here.
Keywords: luteolin; h2o2 induced; ampk nrf2; protects chondrocytes ... See more keywords
Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-κB pathways.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.2139/ssrn.4225767
Abstract: PHARMACOLOGICAL RELEVANCE Indirubin (IR) is a key active ingredient in the traditional Chinese medication QingDai, also called indigo naturalis, which are extensively used in China to treat chronic diseases, such as inflammation and cancer. However,… read more here.
Keywords: chondrocytes alleviates; expression; indirubin protects; protects chondrocytes ... See more keywords
Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries
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DOI: 10.3389/fphar.2021.703847
Abstract: Physiological mechanical stimulation has been shown to promote chondrogenesis, but excessive mechanical loading results in cartilage degradation. Currently, the underlying mechanotransduction pathways in the context of physiological and injurious loading are not fully understood. In… read more here.
Keywords: mechanical overloading; chondrocytes mechanical; overloading induced; protects chondrocytes ... See more keywords