Activation of G-protein-coupled receptor 30 protects neurons against excitotoxicity through inhibiting excessive autophagy induced by glutamate.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00287
Abstract: Autophagy is a protecting intracellular pathway to transmit unnecessary or dysfunctional components to the lysosome for degeneration. Autophagic imbalance is connected with neurodegeneration. Neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, and Huntington's disease are closely… read more here.
Keywords: neurons excitotoxicity; protects neurons; autophagy; excessive autophagy ... See more keywords
Type I interferon protects neurons from prions in in vivo models
Sign Up to like & getrecommendations! Published in 2019 at "Brain"
DOI: 10.1093/brain/awz016
Abstract: Using cell culture and animal models of prion diseases, Ishibashi et al. show that type I interferon signalling interferes with prion infection in mammals. A selective type I interferon receptor agonist inhibits prion invasion and… read more here.
Keywords: type interferon; prion; interferon protects; interferon ... See more keywords
Procyanidin B2 Protects Neurons from Oxidative, Nitrosative, and Excitotoxic Stress
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DOI: 10.3390/antiox6040077
Abstract: The aberrant generation of oxygen and nitrogen free radicals can cause severe damage to key cellular components, resulting in cell apoptosis. Similarly, excitotoxicity leads to protease activation and mitochondrial dysfunction, which subsequently causes cell death.… read more here.
Keywords: pb2; procyanidin protects; apoptosis; neurons oxidative ... See more keywords