HIF-1α protects osteoblasts from ROS-induced apoptosis
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DOI: 10.1080/10715762.2022.2037581
Abstract: Abstract The regulatory mechanism of hypoxia-inducible factor-1α (HIF-1α) is complex. HIF-1α may inhibit or promote apoptosis in osteoblasts under different physiological conditions, and induce bone regeneration and repair injury in coordination with angiogenesis. The relationship… read more here.
Keywords: apoptosis; hif protects; h2o2 induced; hif ... See more keywords
Activation of Nrf2 by MIND4-17 protects osteoblasts from hydrogen peroxide-induced oxidative stress
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DOI: 10.18632/oncotarget.22360
Abstract: MIND4-17 is a recently developed NF-E2-related factor 2 (Nrf2) activator, which uniquely causes Nrf2 disassociation from Keap1. Here, we showed that pretreatment with MIND4-17 significantly inhibited hydrogen peroxide (H2O2)-induced viability reduction of primary osteoblasts and… read more here.
Keywords: mind4; protects osteoblasts; h2o2; hydrogen peroxide ... See more keywords