LAUSR

Effect of C-Reactive Protein on Lipoprotein(a)-Associated Cardiovascular Risk in Optimally Treated Patients With High-Risk Vascular Disease: A Prespecified Secondary Analysis of the ACCELERATE Trial.

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0 Published in 2020 at "JAMA cardiology"

DOI: 10.1001/jamacardio.2020.2413

Abstract: Importance Although lipoprotein(a) (Lp[a]) is a causal genetic risk factor for atherosclerotic cardiovascular disease, it remains unclear which patients with established atherosclerotic cardiovascular disease stand to benefit the most from Lp(a) lowering. Whether inflammation can… read more here.

Keywords: protein; risk; analysis; high risk ... See more keywords

Association Between Plant and Animal Protein Intake and Overall and Cause-Specific Mortality.

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0 Published in 2020 at "JAMA internal medicine"

DOI: 10.1001/jamainternmed.2020.2790

Abstract: Importance Although emphasis has recently been placed on the importance of high-protein diets to overall health, a comprehensive analysis of long-term cause-specific mortality in association with the intake of plant protein and animal protein has… read more here.

Keywords: protein; risk; plant protein; mortality ... See more keywords

Hsp70 – a master regulator in protein degradation

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1 Published in 2017 at "FEBS Letters"

DOI: 10.1002/1873-3468.12751

Abstract: Proteostasis, the controlled balance of protein synthesis, folding, assembly, trafficking and degradation, is a paramount necessity for cell homeostasis. Impaired proteostasis is a hallmark of ageing and of many human diseases. Molecular chaperones are essential… read more here.

Keywords: protein; degradation; hsp70 master; protein degradation ... See more keywords

Diurnal protein oscillation profiles in Drosophila head

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0 Published in 2018 at "FEBS Letters"

DOI: 10.1002/1873-3468.13267

Abstract: Circadian clocks control daily rhythms in physiology, metabolism and behaviour in most organisms. Proteome‐wide analysis of protein oscillations is still lacking in Drosophila. In this study, the total protein and phosphorylated protein in Drosophila heads… read more here.

Keywords: protein; diurnal protein; oscillating proteins; profiles drosophila ... See more keywords

Characterizing the binding of dopamine D1–D2 receptors in vitro and in temporal and frontal lobe tissue total protein

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1 Published in 2019 at "FEBS Letters"

DOI: 10.1002/1873-3468.13351

Abstract: Dysfunction of the dopaminergic pathway is linked to numerous diseases of the nervous system. The D1–D2 receptor heteromer is known to play a role in certain neuropsychiatric disorders, such as depression. Here, we synthesized an… read more here.

Keywords: protein; lobe tissue; total protein; frontal lobe ... See more keywords

Lon domain‐containing protein 1 represses thioredoxin y2 and regulates ROS levels in Arabidopsis chloroplasts

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0 Published in 2019 at "FEBS Letters"

DOI: 10.1002/1873-3468.13664

Abstract: Plant thioredoxins (Trxs) act as antioxidants and function as redox regulators in the chloroplast. Although the regulation of ROS in chloroplasts is well elucidated, the precise regulation mechanism of Trx remains unknown. Here, we characterize… read more here.

Keywords: protein; domain containing; lon domain; lcp1 ... See more keywords

Engineering protein fragments via evolutionary and protein–protein interaction algorithms: de novo design of peptide inhibitors for FOF1‐ATP synthase

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0 Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13988

Abstract: Enzyme subunit interfaces have remarkable potential in drug design as both target and scaffold for their own inhibitors. We show an evolution‐driven strategy for the de novo design of peptide inhibitors targeting interfaces of the… read more here.

Keywords: protein; atp synthase; peptide; novo design ... See more keywords

An immunomodulatory role for the Mycobacterium tuberculosis Acr protein in the formation of the tuberculous granuloma

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0 Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13998

Abstract: The tuberculous granuloma is a compact aggregate of dormant bacteria encapsulated by host macrophages. It is commonly regarded as a product of the host defense designed to isolate infectious mycobacteria. This work demonstrates that exposure… read more here.

Keywords: protein; mycobacterium; tuberculous granuloma; immunomodulatory role ... See more keywords

Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function

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0 Published in 2021 at "FEBS Letters"

DOI: 10.1002/1873-3468.14072

Abstract: In two proof‐of‐concept studies, we established and validated the Bacterial Growth Inhibition Screen (BGIS), which explores recombinant protein toxicity in Escherichia coli as a largely overlooked and alternative means for basic characterization of functional eukaryotic… read more here.

Keywords: protein; bgis; protein toxicity; recombinant protein ... See more keywords

An endogenous bornavirus‐like nucleoprotein in miniopterid bats retains the RNA‐binding properties of the original viral protein

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1 Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14290

Abstract: Endogenous bornavirus‐like nucleoprotein elements (EBLNs) are sequences derived from bornaviral N genes in vertebrate genomes. Some EBLNs have been suggested to encode functional proteins in host cells; however, little is known about their evolution and… read more here.

Keywords: rna binding; like nucleoprotein; endogenous bornavirus; protein ... See more keywords

Arginyl‐tRNA‐protein transferase 1 (ATE1) promotes melanoma cell growth and migration

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2 Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14376

Abstract: Arginyl‐tRNA‐protein transferase 1 (ATE1) catalyses N‐terminal protein arginylation, a post‐translational modification implicated in cell migration, invasion and the cellular stress response. Herein, we report that ATE1 is overexpressed in NRAS‐mutant melanomas, while it is downregulated… read more here.

Keywords: cell; arginyl trna; melanoma cell; ate1 ... See more keywords