Multivariate Control of Transcript to Protein Variability in Single Mammalian Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cell systems"
DOI: 10.1016/j.cels.2018.09.001
Abstract: A long-standing question in quantitative biology is the relationship between mRNA and protein levels of the same gene. Here, we measured mRNA and protein abundance, the phenotypic state, and the population context in thousands of… read more here.
Keywords: cell; mrna protein; protein abundance; phenotypic state ... See more keywords
Ras Post-transcriptionally Enhances a Pre-malignantly Primed EMT to Promote Invasion
Sign Up to like & getrecommendations! Published in 2018 at "iScience"
DOI: 10.1016/j.isci.2018.05.011
Abstract: Summary Epithelial-to-mesenchymal transition (EMT) is integral to cancer progression, with considerable evidence that EMT has multiple intermediary stages. Understanding the mechanisms of this stepwise activation is of great interest. We recreated a genetically defined model… read more here.
Keywords: post transcriptionally; invasion; transcriptionally enhances; protein abundance ... See more keywords
Quantitative proteomics of milk whey reveals breed and season specific variation in protein abundance in Holstein Friesian cow and Murrah buffalo.
Sign Up to like & getrecommendations! Published in 2019 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2019.07.001
Abstract: Bovine milk contains different components with nutritional and immunological benefits. It is easily accessible and a rich source of potential markers reflective of pathophysiological conditions; however, little is known about the changes in protein abundance… read more here.
Keywords: milk; buffalo; friesian cow; protein abundance ... See more keywords
A systematic study of the determinants of protein abundance memory in cell lineage
Sign Up to like & getrecommendations! Published in 2018 at "Science Bulletin"
DOI: 10.1016/j.scib.2018.07.010
Abstract: Proteins are essential players of life activities. Intracellular protein levels directly affect cellular functions and cell fate. Upon cell division, the proteins in the mother cell are inherited by the daughters. However, what factors and… read more here.
Keywords: memory; study determinants; protein abundance; cell ... See more keywords
Optogenetic Downregulation of Protein Levels with an Ultrasensitive Switch.
Sign Up to like & getrecommendations! Published in 2019 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00471
Abstract: Optogenetic control of protein activity is a versatile technique to gain control over cellular processes, for example, for biomedical and biotechnological applications. Among other techniques, the regulation of protein abundance by controlling either transcription or… read more here.
Keywords: protein; control; optogenetic downregulation; protein abundance ... See more keywords
NUMB facilitates autophagy initiation through targeting SCFβ-TrCP2 complex.
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00930-3
Abstract: Given the critical role of SCF E3 ligases in autophagy by modulating the protein stability of various autophagic components, the activity of SCF should be tightly controlled to maintain the autophagic flux. We here showed… read more here.
Keywords: protein abundance; scf trcp2; numb facilitates; trcp2 ... See more keywords
Using protein turnover to expand the applications of transcriptomics
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83886-7
Abstract: RNA expression and protein abundance are often at odds when measured in parallel, raising questions about the functional implications of transcriptomics data. Here, we present the concept of persistence, which attempts to address this challenge… read more here.
Keywords: protein; protein turnover; turnover expand; protein abundance ... See more keywords
Low Complexity Regions in Mammalian Proteins are Associated with Low Protein Abundance and High Transcript Abundance
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac087
Abstract: Abstract Low Complexity Regions (LCRs) are present in a surprisingly large number of eukaryotic proteins. These highly repetitive and compositionally biased sequences are often structurally disordered, bind promiscuously, and evolve rapidly. Frequently studied in terms… read more here.
Keywords: low complexity; abundance; transcript abundance; protein abundance ... See more keywords
A novel active transposon creates allelic variation through altered translation rate to influence protein abundance
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1195
Abstract: Abstract Protein translation is tightly and precisely controlled by multiple mechanisms including upstream open reading frames (uORFs), but the origins of uORFs and their role in maize are largely unexplored. In this study, an active… read more here.
Keywords: protein abundance; translation rate; influence protein; abundance ... See more keywords
Protein prediction models support widespread post-transcriptional regulation of protein abundance by interacting partners
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Computational Biology"
DOI: 10.1101/2022.03.14.484316
Abstract: Protein and mRNA levels correlate only moderately. The availability of proteogenomics data sets with protein and transcript measurements from matching samples is providing new opportunities to assess the degree to which protein levels in a… read more here.
Keywords: protein abundance; abundance; prediction models; interacting partners ... See more keywords
Gestational Age–Dependent Abundance of Human Placental Transporters as Determined by Quantitative Targeted Proteomics
Sign Up to like & getrecommendations! Published in 2020 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.120.000067
Abstract: Some women take medication during pregnancy to address a variety of clinical conditions. Because of ethical and logistical concerns, it is impossible to determine fetal drug exposure, and therefore fetal risk, during pregnancy. Hence, alternative… read more here.
Keywords: abundance; protein abundance; gestational age; maternal fetal ... See more keywords