The Role of Protein Acetylation in Centrosome Biology.
Sign Up to like & getrecommendations! Published in 2019 at "Results and problems in cell differentiation"
DOI: 10.1007/978-3-030-23173-6_2
Abstract: Acetylation is among the most prevalent posttranslational modifications in cells and regulates a number of physiological processes such as gene transcription, cell metabolism, and cell signaling. Although initially discovered on nuclear histones, many non-nuclear proteins… read more here.
Keywords: protein acetylation; acetylation; acetylation centrosome; biology ... See more keywords
Protein acetylation in the critical biological processes in protozoan parasites.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in parasitology"
DOI: 10.1016/j.pt.2021.04.008
Abstract: Protein lysine acetylation has emerged as a major regulatory post-translational modification in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone proteins involved in several cellular… read more here.
Keywords: protein acetylation; acetylation; protozoan parasites; critical biological ... See more keywords
Revealing dynamic protein acetylation across subcellular compartments.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.0c00088
Abstract: Protein acetylation is a widespread post-translational modification implicated in many cellular processes. Recent advances in mass spectrometry have enabled the cataloging of thousands of sites throughout the cell, however identifying regulatory acetylation marks have proven… read more here.
Keywords: protein acetylation; acetylation; site specific; revealing dynamic ... See more keywords
Bioorthogonal Reporters for Detecting and Profiling Protein Acetylation and Acylation
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DOI: 10.1177/2472555219887144
Abstract: Protein acylation, exemplified by lysine acetylation, is a type of indispensable and widespread protein posttranslational modification in eukaryotes. Functional annotation of various lysine acetyltransferases (KATs) is critical to understanding their regulatory roles in abundant biological… read more here.
Keywords: protein acetylation; acetylation; acylation; biology ... See more keywords
Genome-scale analysis of regulatory protein acetylation enzymes from photosynthetic eukaryotes
Sign Up to like & getrecommendations! Published in 2017 at "BMC Genomics"
DOI: 10.1186/s12864-017-3894-0
Abstract: BackgroundReversible protein acetylation occurring on Lys-Ne has emerged as a key regulatory post-translational modification in eukaryotes. It is mediated by two groups of enzymes: lysine acetyltransferases (KATs) and lysine deacetylases (KDACs) that catalyze the addition… read more here.
Keywords: protein; protein acetylation; class; analysis ... See more keywords
The role of protein acetylation in carcinogenesis and targeted drug discovery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.972312
Abstract: Protein acetylation is a reversible post-translational modification, and is involved in many biological processes in cells, such as transcriptional regulation, DNA damage repair, and energy metabolism, which is an important molecular event and is associated… read more here.
Keywords: acetylation; role protein; protein acetylation; carcinogenesis ... See more keywords
Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.01604
Abstract: Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity to an existing proteome. The large number of known PTMs highlights the many ways that cells can modify their proteins to respond to diverse stimuli. Recently,… read more here.
Keywords: protein; protein acetylation; acetylation; mechanism ... See more keywords
HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines11010088
Abstract: Epilepsy is a common and severe chronic neurological disorder. Recently, post-translational modification (PTM) mechanisms, especially protein acetylation modifications, have been widely studied in various epilepsy models or patients. Acetylation is regulated by two classes of… read more here.
Keywords: acetylation; treatment epilepsy; protein acetylation; hat hdac ... See more keywords
Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Metabolites"
DOI: 10.3390/metabo11040216
Abstract: Metabolic reprogramming is an emerging hallmark of cancer and is driven by abnormalities of oncogenes and tumor suppressors. Accelerated metabolism causes cancer cell aggression through the dysregulation of rate-limiting metabolic enzymes as well as by… read more here.
Keywords: cancer; protein acetylation; genetics; interface genetics ... See more keywords
Histone acetyltransferase inhibitors antagonize AMP-activated protein kinase in postmortem glycolysis
Sign Up to like & getrecommendations! Published in 2017 at "Asian-Australasian Journal of Animal Sciences"
DOI: 10.5713/ajas.16.0556
Abstract: Objective The purpose of this study was to investigate the influence of AMP-activated protein kinase (AMPK) activation on protein acetylation and glycolysis in postmortem muscle to better understand the mechanism by which AMPK regulates postmortem… read more here.
Keywords: protein acetylation; glycolysis; postmortem glycolysis; postmortem ... See more keywords