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Published in 2019 at "National Science Review"
DOI: 10.1093/nsr/nwz063
Abstract: Time-resolved tools for activating proteins of interest in living systems can allow monitoring of the dynamics of biological processes such as signal transduction. Various approaches have been developed to engineer both constitutive and inducible protein…
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Keywords:
protein;
computationally designed;
protein activation;
active site ... See more keywords
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Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1171855
Abstract: N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide is a newly-designed pain killer selectively activating G-protein-coupled mu-opioid receptors (MOR) in acidic injured tissues, and therefore devoid of central side effects which are typically elicited at normal pH values in healthy tissues.…
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Keywords:
calcium;
calcium currents;
phosphorylation dependent;
protein ... See more keywords