Enhanced Intracellular Protein Activity by Caveolae-Mediated Endocytosis of Conjugated Polymer/Protein Complexes.
Sign Up to like & getrecommendations! Published in 2025 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202400557
Abstract: Conjugated polymers (CPs) with rigid hydrophobic backbones and polar side chains are known for their efficient cellular entry using various endocytic pathways. Here, the efficient delivery of ribonuclease A (RNase A) into the cytosol of… read more here.
Keywords: intracellular protein; enhanced intracellular; protein activity; activity caveolae ... See more keywords
Optogenetic Imaging of Protein Activity Using Two-Photon Fluorescence Lifetime Imaging Microscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-8763-4_18
Abstract: Spatiotemporal dynamics of cellular proteins, including protein-protein interactions and conformational changes, is essential for understanding cellular functions such as synaptic plasticity, cell motility, and cell division. One of the best ways to understand the mechanisms… read more here.
Keywords: protein; protein activity; microscopy; two photon ... See more keywords
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism: a case report
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers of Medicine"
DOI: 10.1007/s11684-017-0553-4
Abstract: Antithrombin and protein C are two crucial members in the anticoagulant system and play important roles in hemostasis. Mutations in SERPINC1 and PROC lead to deficiency or dysfunction of the two proteins, which could result… read more here.
Keywords: antithrombin deficiency; protein activity; deficiency; decreased protein ... See more keywords
Engineering genetically-encoded tools for optogenetic control of protein activity.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.05.001
Abstract: Optogenetic tools offer fast and reversible control of protein activity with subcellular spatial precision. In the past few years, remarkable progress has been made in engineering photoactivatable systems regulating the activity of cellular proteins. In… read more here.
Keywords: control protein; protein activity; activity; engineering ... See more keywords
Reducing SARS-CoV-2 pathological protein activity with small molecules
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2021.03.012
Abstract: Coronaviruses are dangerous human and animal pathogens. The newly identified coronavirus SARS-CoV-2 is the causative agent of COVID-19 outbreak, which is a real threat to human health and life. The world has been struggling with… read more here.
Keywords: protein activity; pathological protein; cov pathological; sars cov ... See more keywords
Toward Comprehensive Allosteric Control over Protein Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.1016/j.str.2019.01.014
Abstract: Universality of allosteric signaling in proteins, molecular machines, and receptors complemented by the great advantages of prospected allosteric drugs in the highly specific, non-competitive, and modulatory nature of their actions calls for deeper theoretical understanding… read more here.
Keywords: protein activity; allosteric control; allosteric communication;
Transient Photo-Inactivation of Cell Membrane Protein Activity without Genetic Modification by Molecular Hyperthermia.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.9b01993
Abstract: Precise manipulation of protein activity in living systems has broad applications in biomedical sciences. However, it is challenging to use light to manipulate protein activity in living systems without genetic modification. Here, we report a… read more here.
Keywords: protein; protein activity; photo; without genetic ... See more keywords
HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2515747122
Abstract: Significance Crossovers are essential to produce gametes by promoting the proper segregation of the homologous chromosomes. But, if misregulated, they can lead to genetic disorders, miscarriage, and infertility. Their formation depends on the conserved pro-crossover… read more here.
Keywords: heip1 orchestrates; crossover protein; protein activity; protein ... See more keywords
Single-cell protein activity analysis reveals a novel subpopulation of chondrocytes and the corresponding key master regulator proteins associated with anti-senescence and OA progression
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1077003
Abstract: Background Osteoarthritis (OA) is a prevalent senescence-related disease with substantial joint pain, loss of joint function, and cartilage degeneration. Because of the paucity of single-cell studies of OA and the gene dropout problem of single-cell… read more here.
Keywords: cell; protein activity; senescence; single cell ... See more keywords
Protein Activity Sensing in Bacteria in Regulating Metabolism and Motility
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.03055
Abstract: Bacteria have evolved complex sensing and signaling systems to react to their changing environments, most of which are present in all domains of life. Canonical bacterial sensing and signaling modules, such as membrane-bound ligand-binding receptors… read more here.
Keywords: protein activity; sensing bacteria; bacteria regulating; motility ... See more keywords
Membrane Protein Activity Induces Specific Molecular Changes in Nanodiscs Monitored by FTIR Difference Spectroscopy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.915328
Abstract: It is well known that lipids neighboring integral membrane proteins directly influence their function. The opposite effect is true as well, as membrane proteins undergo structural changes after activation and thus perturb the lipidic environment.… read more here.
Keywords: membrane proteins; protein activity; spectroscopy; spectroscopy membrane ... See more keywords