The protein adduction derived from reactive metabolites of multiple furanoids in Cortex Dictamni-treated mice.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2022.01.001
Abstract: The association of herb medicine Cortex Dictamni (CD) with severe even fatal hepatotoxicity has been widely reported. Recently, we demonstrated that the metabolic activation of at least ten furanoids in CD was responsible for the… read more here.
Keywords: protein adduction; reactive metabolites; mice; liver injury ... See more keywords
Cysteine-Based Protein Covalent Binding and Hepatotoxicity Induced by Emodin.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00358
Abstract: Emodin (EMD) is a major ingredient of Polygonum multiflorum Thunb. (PMT), which has shown adverse liver reactions. Despite multiple pharmacological activities, EMD is reported to show various toxicities. Our early study demonstrated the reactivity of… read more here.
Keywords: hepatotoxicity; covalent; hepatotoxicity induced; protein adduction ... See more keywords
Immunochemical and LC-MS/MS Detection of Protein Adduction Resulting from Metabolic Activation of Columbin In Vitro and In Vivo.
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DOI: 10.1021/acs.chemrestox.3c00006
Abstract: Columbin (CLB) is a diterpenoid furanolactone compound occurring in some herbal medicines. Administration of CLB has been reported to induce liver injury. The reported CLB hepatotoxicity is suggested to require metabolism to a cis-enedial intermediate.… read more here.
Keywords: resulting metabolic; metabolic activation; adduction resulting; adduction ... See more keywords
The Role of Protein Adduction in Toxic Neuropathies of Exogenous and Endogenous Origin
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DOI: 10.3390/toxics9050098
Abstract: The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and… read more here.
Keywords: protein adduction; adduction toxic; toxic neuropathies; exogenous endogenous ... See more keywords