Alkylated glutamic acid and histidine derived from protein-adducts indicate exposure to sulfur mustard in avian serum.
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DOI: 10.1002/dta.3236
Abstract: Sulfur mustard (SM, bis(2-chloroethyl)-sulfide) is a banned chemical warfare agent deployed in the violent conflict in the Middle East poisoning humans and animals. For legal reasons bioanalytical methods are mandatory proving exposure to SM. Reaction… read more here.
Keywords: avian serum; sulfur mustard; serum; hete ... See more keywords
Measurement of 4-Hydroxynonenal (4-HNE) Protein Adducts by ELISA.
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DOI: 10.1007/978-1-4939-9463-2_4
Abstract: Enzyme linked immunosorbent assay (ELISA) is a widely used technique for the measurement of antigens and antibodies alike. We describe here procedures, indirect ELISA and sandwich ELISA for the detection of 4-hydroxynonenal protein adducts. These… read more here.
Keywords: protein; protein adducts; hne protein; adducts elisa ... See more keywords
Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver.
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DOI: 10.1016/j.lfs.2019.05.062
Abstract: AIM Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate… read more here.
Keywords: protein adducts; induced hepatotoxicity; generation; apap ... See more keywords
Role of extracellular vesicles in release of protein adducts after acetaminophen-induced liver injury in mice and humans.
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DOI: 10.1016/j.toxlet.2018.11.005
Abstract: Formation of acetaminophen (APAP) protein adducts are a critical feature of APAP hepatotoxicity, and circulating protein adducts have recently been utilized in bioassays for identification of APAP overdose in humans. Despite their clinical significance, mechanisms… read more here.
Keywords: protein adducts; apap overdose; release; apap protein ... See more keywords
Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid
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DOI: 10.3390/toxins14060377
Abstract: Pyrrolizidine alkaloids (PAs) have been found in over 6000 plants worldwide and represent the most common hepatotoxic phytotoxins. Catalyzed by hepatic cytochrome P450 enzymes, PAs are metabolized into reactive pyrrolic metabolites, which can alkylate cellular… read more here.
Keywords: pyrrole dna; protein adducts; pyrrole; pyrrole protein ... See more keywords