Light‐Driven Micromotors to Dissociate Protein Aggregates That Cause Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202106699
Abstract: Nowadays, microrobots are considered appealing mobile carriers for clinical therapies. In this sense, high expectations against unmet medical challenges have been created around microswimmers that combine autonomous navigation with enhanced abilities to perform specific tasks.… read more here.
Keywords: micromotors dissociate; dissociate protein; light driven; protein aggregates ... See more keywords
Thiophene‐Based Ligands: Design, Synthesis and Their Utilization for Optical Assignment of Polymorphic‐Disease‐Associated Protein Aggregates
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300044
Abstract: The development of ligands for detecting protein aggregates is of great interest, as these aggregated proteinaceous species are the pathological hallmarks of several devastating diseases, including Alzheimer's disease. In this regard, thiophene‐based ligands have emerged… read more here.
Keywords: disease; based ligands; thiophene based; protein aggregates ... See more keywords
Congo Red-Derived Carbon Dots: Simultaneously as Fluorescence Probe for Protein Aggregates, Inhibitor for Protein Aggregation, and Scavenger of Free Radicals.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202205634
Abstract: The pathological aggregation of some proteins is claimed to be highly related to several human diseases, such as β-amyloid 1-42 (Aβ42 ) to Alzheimer's disease (AD), islet amyloid polypeptide, and insulin to type 2 diabetes… read more here.
Keywords: aggregation; carbon; congo red; protein aggregation ... See more keywords
Methods for the Characterization of Protein Aggregates.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1859-2_29
Abstract: The physicochemical characterization of protein aggregates yields an important contribution to further our understanding on many diseases for which the formation of protein aggregates is one of the pathological hallmarks. On the other hand, bacterial… read more here.
Keywords: microscopy; protein aggregates; characterization protein; methods characterization ... See more keywords
Advances on Size Exclusion Chromatography and Applications on the Analysis of Protein Biopharmaceuticals and Protein Aggregates: A Mini Review
Sign Up to like & getrecommendations! Published in 2017 at "Chromatographia"
DOI: 10.1007/s10337-017-3380-5
Abstract: Biopharmaceutical drugs are large, complex protein molecules derived from living cells. The characterization of the protein-based products is a complicated and challenging task necessary to guarantee their efficacy and safety. A major concern in manufacturing… read more here.
Keywords: protein; protein aggregates; protein biopharmaceuticals; exclusion chromatography ... See more keywords
The proteome of neurofilament-containing protein aggregates in blood
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2018.04.010
Abstract: Protein aggregation in biofluids is a poorly understood phenomenon. Under normal physiological conditions, fluid-borne aggregates may contain plasma or cell proteins prone to aggregation. Recent observations suggest that neurofilaments (Nf), the building blocks of neurons… read more here.
Keywords: protein; aggregates blood; proteome neurofilament; protein aggregates ... See more keywords
Adsorption layer formation in dispersions of protein aggregates.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in colloid and interface science"
DOI: 10.1016/j.cis.2019.102086
Abstract: The review discusses recent results on the adsorption of amyloid fibrils and protein microgels at liquid/fluid interfaces. The application of the shear and dilational surface rheology, atomic force microscopy and passive particle probe tracking allowed… read more here.
Keywords: adsorption; surface; protein aggregates; formation ... See more keywords
Prion-like properties of assembled TDP-43
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2019.11.018
Abstract: A neuropathological hallmark of most neurodegenerative diseases is the appearance of characteristic inclusions composed of misfolded proteins in brains of patients. Increasing evidence shows that aggregation-prone proteins such as tau, α-synuclein and TDP-43 are accumulated… read more here.
Keywords: prion like; prion; protein aggregates; properties assembled ... See more keywords
Test models for the evaluation of immunogenicity of protein aggregates
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.01.015
Abstract: &NA; Protein aggregates have been discussed for a long time as a potential risk factor for immunogenicity in patients. Meanwhile, many research groups have investigated the immunogenicity of differently produced aggregates using in vitro or… read more here.
Keywords: immunogenicity protein; immunogenicity; protein aggregates; evaluation immunogenicity ... See more keywords
Thiol oxidation and di-tyrosine formation in human plasma proteins induced by inflammatory concentrations of hypochlorous acid.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2016.10.008
Abstract: In this study, we assessed the oxidative damage occurring in plasma proteins when human blood was exposed to inflammatory concentrations of hypochlorous acid (HOCl). We used specific thiol labelling and Western blot analyses to determine… read more here.
Keywords: protein; oxidation; protein aggregates; hocl ... See more keywords
Cellular Handling of Protein Aggregates by Disaggregation Machines.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.01.004
Abstract: Both acute proteotoxic stresses that unfold proteins and expression of disease-causing mutant proteins that expose aggregation-prone regions can promote protein aggregation. Protein aggregates can interfere with cellular processes and deplete factors crucial for protein homeostasis.… read more here.
Keywords: protein; disaggregation; cellular handling; disaggregation machines ... See more keywords