SARS‐CoV‐2 spike protein aggregation is triggered by bacterial lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2022 at "Febs Letters"
DOI: 10.1002/1873-3468.14490
Abstract: SARS‐CoV‐2 spike (S) protein is crucial for virus invasion in COVID‐19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of… read more here.
Keywords: aggregation; cov spike; protein aggregation; spike protein ... See more keywords
Cell‐Penetrating Chaperone Peptide Prevents Protein Aggregation and Protects against Cell Apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700095
Abstract: Many of the newly discovered therapeutic peptides and molecules are limited by their inability to cross the cell membrane. In the present study, a cell‐penetrating peptide (CPP), VPTLK, derived from Ku70 protein, is employed to… read more here.
Keywords: peptide; cell; cell penetrating; protein aggregation ... See more keywords
Amyloid‐Like Protein Aggregation Toward Pesticide Reduction
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105106
Abstract: Pesticide overuse is a major global problem and the cause of this problem is noticeable pesticide loss from undesired bouncing of sprayed pesticide droplets and rain erosion. This further becomes a primary source of soil… read more here.
Keywords: amyloid like; pesticide; like protein; protein aggregation ... See more keywords
Tau peptides and tau mutant protein aggregation inhibition by cationic polyethyleneimine and polyarginine
Sign Up to like & getrecommendations! Published in 2017 at "Biopolymers"
DOI: 10.1002/bip.23024
Abstract: Tau protein plays a major role in Alzheimer's disease. The tau protein loses its functionality by self‐aggregation due to the two six‐amino acid sequences VQIVYK and VQIINK of the protein. Hence it is imperative to… read more here.
Keywords: protein; aggregation; tau mutant; protein aggregation ... See more keywords
Inhibition of Amyloid Protein Aggregation Using Selected Peptidomimetics
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200499
Abstract: Aberrant protein aggregation leads to the formation of amyloid fibrils. This phenomenon is linked to the development of more than 40 irremediable diseases such as Alzheimer's disease, Parkinson's disease, type 2 diabetes, and cancer. Plenty… read more here.
Keywords: aggregation; inhibition amyloid; amyloid protein; protein aggregation ... See more keywords
Congo Red-Derived Carbon Dots: Simultaneously as Fluorescence Probe for Protein Aggregates, Inhibitor for Protein Aggregation, and Scavenger of Free Radicals.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202205634
Abstract: The pathological aggregation of some proteins is claimed to be highly related to several human diseases, such as β-amyloid 1-42 (Aβ42 ) to Alzheimer's disease (AD), islet amyloid polypeptide, and insulin to type 2 diabetes… read more here.
Keywords: aggregation; carbon; congo red; protein aggregation ... See more keywords
Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_60
Abstract: The formation of protein aggregates and inclusions in the brain and spinal cord is a common neuropathological feature of a number of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS),… read more here.
Keywords: protein; small molecule; neurodegenerative diseases; protein aggregation ... See more keywords
Inhibition of mitophagy decreases survival of Caenorhabditis elegans by increasing protein aggregation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3418-5
Abstract: Autophagy of mitochondria, i.e., mitophagy, plays a crucial role in coping with stressors in the aging process, metabolic disturbances, and neurological disorders. Impairments of the process might consequently lead to enhanced accumulation of aged and… read more here.
Keywords: inhibition mitophagy; mitophagy decreases; aggregation; caenorhabditis elegans ... See more keywords
Rational design, synthesis and activities of hydroxylated chalcones as highly potent dual functional agents against Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105662
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the extracellular amyloid plaques in the brain. Recent studies have shown that ferroptosis, a recently identified cell death pathway associated with the accumulation of lipid… read more here.
Keywords: dual functional; disease; compound; protein aggregation ... See more keywords
Small molecule probes of protein aggregation.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.06.008
Abstract: Understanding the mechanisms of amyloid formation and toxicity remain major challenges. Although substantial progress has been made in the development of methods able to identify the species formed during self-assembly and to describe the kinetic… read more here.
Keywords: aggregation; small molecule; probes protein; protein aggregation ... See more keywords
Hydrotropic function of ATP in the crystalline lens.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107862
Abstract: The theory proposed herein is presented to explain the unexpectedly high concentration of ATP and provide evidence to support its hydrotropic function in the crystalline lens determined using 31P NMR. The lens, historically considered to… read more here.
Keywords: atp; water; hydrotropic function; protein aggregation ... See more keywords