Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes.
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DOI: 10.1016/j.ajhg.2016.09.020
Abstract: The allosteric regulation triggering the protein's functional activity via conformational changes is an intrinsic function of protein under many physiological and pathological conditions, including cancer. Identification of the biological effects of specific somatic variants on allosteric… read more here.
Keywords: cancer; cancer genomes; allosteric regulation; protein allosteric ... See more keywords