Protein Allostery Study in Cells Using NMR Spectroscopy.
Sign Up to like & getrecommendations! Published in 2024 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c00360
Abstract: Protein allostery is commonly observed in vitro. But how protein allostery behaves in cells is unknown. In this work, a protein monomer-dimer equilibrium system was built with the allosteric effect on the binding characterized using… read more here.
Keywords: spectroscopy; nmr spectroscopy; using nmr; protein allostery ... See more keywords
The value of protein allostery in rational anticancer drug design: an update
Sign Up to like & getrecommendations! Published in 2024 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2024.2384467
Abstract: ABSTRACT Introduction Allosteric drugs are advantageous. However, they still face hurdles, including identification of allosteric sites that will effectively alter the active site. Current strategies largely focus on identifying pockets away from the active sites… read more here.
Keywords: value protein; protein allostery; drug design; drug ... See more keywords