Conjugation-Free Multilamellar Protein-Lipid Hybrid Vesicles for Multifaceted Immune Responses.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101239
Abstract: Various lipid-based nanocarriers have been developed for the co-delivery of protein antigens with immunological adjuvants. However, their in vivo potency in vaccine delivery is limited by structural instability, which causes off-target delivery and low cross-presentation… read more here.
Keywords: protein; protein antigens; delivery; free multilamellar ... See more keywords
Diagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic review.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of infection and public health"
DOI: 10.1016/j.jiph.2019.12.011
Abstract: The aim of this systematic review was to investigate the studies that evaluated the sensitivity and specificity of serologic tests using recombinant protein antigens from Mycobacterium leprae for leprosy diagnosis. We included 13 studies that… read more here.
Keywords: protein; protein antigens; systematic review; using recombinant ... See more keywords
An alpaca single-domain antibody (VHH) phage-display library constructed by CDR shuffling provided high affinity VHHs against desired protein antigens.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac022
Abstract: Antigen combining sites of the camelid heavy chain antibody variable domain (VHH) are constructed by three complementarity determining regions (CDR1, CDR2, and CDR3). We prepared cDNA using mRNA extracted from peripheral lymphocytes of alpacas that… read more here.
Keywords: display library; vhh; vhh phage; protein antigens ... See more keywords
Making Weak Antigens Strong: Modifying Protein Antigens by Denaturation.
Sign Up to like & getrecommendations! Published in 2018 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.prot099960
Abstract: Many molecules can be made more immunogenic by denaturation. This treatment will change the structure of many compounds, particularly proteins, and expose new epitopes. In addition, heating will often cause protein antigens to aggregate, and,… read more here.
Keywords: protein antigens; antigens strong; denaturation; making weak ... See more keywords
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens *
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13059
Abstract: Antibodies to non‐protein antigens such as nucleic acids, polysaccharides, and glycolipids play important roles in both host defense against microbes and development of autoimmune diseases. Although non‐protein antigens are not recognized by T cells, antibody… read more here.
Keywords: cell; non protein; protein antigens; tolerance ... See more keywords