Salt equilibria in nutritional formulae for infants and young children
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DOI: 10.1016/j.idairyj.2020.104805
Abstract: Abstract The distribution of Ca, Mg, K and Na between the sedimentable (200×g), protein-associated and soluble phase of infant formula (IF; n = 46), follow-on formula (FOF; n = 8), junior growing up milk (jGUM; n = 22) and senior GUM… read more here.
Keywords: nutritional formulae; protein associated; soluble phase; equilibria nutritional ... See more keywords
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01966
Abstract: Adaptor protein 2-associated kinase 1 (AAK1) is a serine/threonine kinase that was identified as a therapeutic target for the potential treatment of neuropathic pain. Inhibition of AAK1 in the central nervous system, particularly within the… read more here.
Keywords: adaptor protein; protein associated; kinase; associated kinase ... See more keywords
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02132
Abstract: Recent mouse knockout studies identified adapter protein-2-associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. BMS-986176/LX-9211 (4), as a highly selective, CNS-penetrable, and potent AAK1 inhibitor, has advanced into phase II human… read more here.
Keywords: aak1; protein associated; associated kinase; neuropathic pain ... See more keywords
Expanding the Spectrum of Early Neuroradiologic Findings in β Propeller Protein-Associated Neurodegeneration
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DOI: 10.3174/ajnr.a7693
Abstract: BACKGROUND AND PURPOSE: β propeller protein-associated neurodegeneration (BPAN) is the most common neurodegeneration with brain iron accumulation disorder. Typical radiologic findings are T2 hypointensity in the substantia nigra and globus pallidus, as well as a… read more here.
Keywords: substantia nigra; protein associated; propeller protein; neurodegeneration ... See more keywords
Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN): Two Phenotypes—Dystonia and Spastic Paraparesis
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DOI: 10.4103/aian.aian_658_22
Abstract: Dear Editor, Neurodegeneration with brain iron accumulation is a group of inherited disorders characterized by cognitive dysfunction and extrapyramidal and pyramidal signs with iron accumulation at the basal ganglia. Identifying single neurodegeneration with brain iron… read more here.
Keywords: protein associated; mitochondrial membrane; neurodegeneration; membrane protein ... See more keywords