Loss of ubiquitinated protein autophagy is compensated by persistent cnc/NFE2L2/Nrf2 antioxidant responses.
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DOI: 10.1080/15548627.2022.2037852
Abstract: SQSTM1/p62-type selective macroautophagy/autophagy receptors cross-link poly-ubiquitinated cargo and autophagosomal LC3/Atg8 proteins to deliver them for lysosomal degradation. Consequently, loss of autophagy leads to accumulation of polyubiquitinated protein aggregates that are also frequently seen in various… read more here.
Keywords: cnc nfe2l2; protein autophagy; autophagy; nfe2l2 nrf2 ... See more keywords