Effective inhibition of C3a-mediated pro-inflammatory response by a human C3a-specific protein binder.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.27309
Abstract: Complement component 3a (C3a) plays a crucial role in the immune response and host defense, but it is also involved in pro-inflammatory responses, causing many inflammatory disorders. Blockade of C3a has been regarded as a… read more here.
Keywords: c3a; protein binder; response; specific protein ... See more keywords
A regulatory SH2 domain-targeting protein binder effectively inhibits the activity of Bruton's tyrosine kinase and its drug-resistant variants.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.006
Abstract: Human Bruton's tyrosine kinase (hBtk) plays a key role in growth and metabolism of B cells, but its dysfunctions cause various B-cell malignancies. Inhibitors targeting the ATP-binding pocket of hBtk have been developed, but they… read more here.
Keywords: protein binder; drug resistant; sh2 domain; activity ... See more keywords
Engineering a Protein Binder Specific for p38α with Interface Expansion.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00408
Abstract: Protein binding specificities can be manipulated by redesigning contacts that already exist at an interface or by expanding the interface to allow interactions with residues adjacent to the original binding site. Previously, we developed a… read more here.
Keywords: protein; engineering protein; monobody; protein binder ... See more keywords
Improving de novo protein binder design with deep learning
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1101/2022.06.15.495993
Abstract: Recently, a pipeline for the design of protein-binding proteins using only the structure of the target protein was reported. Here, the authors report that the incorporation of deep learning methods into the original pipeline increases… read more here.
Keywords: protein binder; design; deep learning; binder design ... See more keywords
PEPscan: A Broad Spectrum Approach for the Characterization of Protein-Binder Interactions?
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12020178
Abstract: In a previous study, we have shown that PEPscan can provide a cheap and rapid means to identify candidate interfering peptides (IPs), i.e., peptides able to disrupt a target protein-protein interaction. PEPscan was shown to… read more here.
Keywords: protein binder; binder interactions; spectrum approach; protein ... See more keywords