Interchain doubly-bridged α-helical peptides for the development of protein binders
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2019.02.013
Abstract: Abstract Constrained peptide scaffolds that are tolerant to extensive sequence manipulation and amenable to bioactive peptide design are of great value to the development of novel protein binders and peptide therapeutics. In this work, we… read more here.
Keywords: protein binders; doubly bridged; helical peptides; bridged helical ... See more keywords
Dissecting the impact of target-binding kinetics of protein binders on tumor localization
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102104
Abstract: Summary Systematic control of in vivo behavior of protein-based therapeutics is considered highly desirable for improving their clinical outcomes. Modulation of biochemical properties including molecular weight, surface charge, and binding affinity has thus been suggested… read more here.
Keywords: protein binders; affinity; binding kinetics; tumor localization ... See more keywords
Abstract WP313: Liposomes With Anti-Fibrin Protein Binders to Target Clot in Stroke
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DOI: 10.1161/str.51.suppl_1.wp313
Abstract: Introduction: Direct clot targeting represents attractive concept for clot imaging as well as targeted delivery of drugs, e.g. thrombolytics. Small protein binders attached to nanoliposomes may target thrombi and deliver drugs although selective affinity to… read more here.
Keywords: protein binders; microscopy; attached nanoliposomes; fibrin ... See more keywords