DPA-Zinc around Polyplexes Acts Like PEG to Reduce Protein Binding while Targeting Cancer Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203252
Abstract: Gene therapy holds great promise as an effective treatment for many diseases of genetic origin. Gene therapy works by employing cationic polymers, liposomes, and nanoparticles to condense DNA into polyplexes via electronic interactions.Then, a therapeutic… read more here.
Keywords: binding targeting; protein binding; targeting cancer; gene ... See more keywords
Elucidation of mode of anticancerous activity of metal guanidinobenzimidazoles: A computational and experimental screening
Sign Up to like & getrecommendations! Published in 2024 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.7654
Abstract: DNA‐binding agents often exhibits dual behavior of simultaneous binding with protein associated with cancerous cell development pathways. This simultaneous protein binding if contributed to malfunctioning of pro‐apoptotic proteins will reduce anticancerous potential of drugs. The… read more here.
Keywords: elucidation; cell; dna binding; dna ... See more keywords
Sensitive protein detection and visualization using protein‐binding peptides
Sign Up to like & getrecommendations! Published in 2020 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.23482
Abstract: Silk sericin (SS) as a silk protein has important applications in biomedical and textile fields, and thus finding a facile method for detecting and imaging it is very important. Here, we show that a free… read more here.
Keywords: detection; detection visualization; protein binding; sensitive protein ... See more keywords
Non‐random distribution of deleterious mutations in the DNA and protein‐binding domains of IRF6 are associated with Van Der Woude syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1355
Abstract: Abstract Background The development of the face occurs during the early days of intrauterine life by the formation of facial processes from the first Pharyngeal arch. Derangement in these well‐organized fusion events results in Orofacial… read more here.
Keywords: van der; der woude; protein binding; binding domains ... See more keywords
Population pharmacokinetics of unbound valproic acid in pediatric epilepsy patients in China: a protein binding model.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of clinical pharmacology"
DOI: 10.1007/s00228-020-03080-y
Abstract: PURPOSE The purpose of this study was to establish a protein binding model of unbound valproic acid (VPA) based on Chinese pediatric patients with epilepsy and provide a reference for clinical medication. METHODS A total… read more here.
Keywords: protein binding; valproic acid; model; binding model ... See more keywords
Identification of potential human targets for epigallocatechin gallate through a novel protein binding site screening approach
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-025-06410-y
Abstract: Epigallocatechin-3-gallate (EGCG), a compound found in green tea, is known for its anticancer properties, although its specific protein targets remain largely undefined. In this study, we identified EGCG targets across the human proteome using a… read more here.
Keywords: binding site; site screening; novel protein; protein ... See more keywords
An Improved Method for Identifying Specific DNA-Protein-Binding Sites In Vitro
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biotechnology"
DOI: 10.1007/s12033-017-9993-y
Abstract: Binding of proteins to specific DNA sequences is essential for a variety of cellular processes such as DNA replication, transcription and responses to external stimuli. Chromatin immunoprecipitation is widely used for determining intracellular DNA fragments… read more here.
Keywords: protein; protein binding; dna; method identifying ... See more keywords
DeepSite: bidirectional LSTM and CNN models for predicting DNA–protein binding
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Machine Learning and Cybernetics"
DOI: 10.1007/s13042-019-00990-x
Abstract: Transcription factors are cis -regulatory molecules that bind to specific sub-regions of DNA promoters and initiate transcription, the process that regulates the conversion of genetic information from DNA to RNA. Several computational methods have been… read more here.
Keywords: protein binding; dna protein; binding sites; cnn ... See more keywords
Formation of glyco-functionalized interfaces for protein binding using polyphenolic glycoside.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate research"
DOI: 10.1016/j.carres.2020.108002
Abstract: In this study, a polyphenolic glycoside (α-glucosyl rutin) was used to form glyco-functionalized interfaces for protein binding. α-Glucosyl rutin was coated onto precious metals, metal oxides, and synthetic polymers, including polyethylene and polytetrafluoroethylene with poor… read more here.
Keywords: protein binding; functionalized interfaces; polyphenolic glycoside; interfaces protein ... See more keywords
A novel strategy for prediction of human plasma protein binding using machine learning techniques
Sign Up to like & getrecommendations! Published in 2020 at "Chemometrics and Intelligent Laboratory Systems"
DOI: 10.1016/j.chemolab.2020.103962
Abstract: Abstract Plasma protein binding (PPB) is a key player of drug ADME (absorption, distribution, metabolism, elimination) behaviors, enabling PPB to have significant impact on drug efficacy and toxicity. As drug discovery enters the era of… read more here.
Keywords: protein binding; plasma protein; drug; prediction ... See more keywords
Dominant entropic binding of perfluoroalkyl substances (PFASs) to albumin protein revealed by 19F NMR.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.128083
Abstract: Mechanistic insight into protein binding by poly- and perfluoroalkyl substances (PFASs) is critical to understanding how PFASs distribute and accumulate within the body and to developing predictive models within and across classes of PFASs. Fluorine… read more here.
Keywords: protein; protein binding; perfluoroalkyl substances; 19f nmr ... See more keywords