Membrane Protein Biogenesis: PAT Complex Pats Membrane Proteins into Shape
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.09.072
Abstract: Membrane proteins with multiple transmembrane domains play essential roles in the cell, but little is known about the machinery involved in the assembly of these domains into functional proteins. Two recent studies report the discovery… read more here.
Keywords: membrane protein; membrane; membrane proteins; protein biogenesis ... See more keywords
Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-91107-4
Abstract: The Sec61 complex translocates nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), providing access to the secretory pathway. In this study, we show that Ipomoeassin-F (Ipom-F), a selective inhibitor of protein… read more here.
Keywords: ipomoeassin disrupts; protein biogenesis; multiple aspects; aspects secretory ... See more keywords
Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress
Sign Up to like & getrecommendations! Published in 2017 at "mBio"
DOI: 10.1128/mbio.01742-17
Abstract: ABSTRACT Copper (Cu) ions serve as catalytic cofactors to drive key biochemical processes, and yet Cu levels that exceed cellular homeostatic control capacity are toxic. The underlying mechanisms for Cu toxicity are poorly understood. During… read more here.
Keywords: cryptococcus neoformans; protein biogenesis; machinery; biogenesis machinery ... See more keywords
Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.207829
Abstract: ABSTRACT Tail-anchored (TA) proteins are transmembrane proteins with a single C-terminal transmembrane domain, which functions as both their subcellular targeting signal and membrane anchor. We show that knockout of TRC40 in cultured human cells has… read more here.
Keywords: biogenesis; protein biogenesis; tail anchored; anchored proteins ... See more keywords