Peptidyl arginine deiminases: detection and functional analysis of protein citrullination.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.01.024
Abstract: Citrullination is a post-translational modification of arginine that is catalyzed by the protein arginine deiminases (PADs). Abnormal citrullination is observed in many autoimmune diseases and cancers. Anti-citrullinated protein antibodies (ACPA) are hallmarks of RA and… read more here.
Keywords: peptidyl arginine; arginine deiminases; citrullination; protein citrullination ... See more keywords
Enabling Global Analysis of Protein Citrullination via Biotin Thiol Tag-Assisted Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03844
Abstract: Citrullination is a key post-translational modification (PTM) that affects protein structures and functions. Although it has been linked to various biological processes and disease pathogenesis, the underlying mechanism remains poorly understood due to a lack… read more here.
Keywords: citrullination; citrullination via; mass spectrometry; thiol tag ... See more keywords
The virtues and vices of protein citrullination
Sign Up to like & getrecommendations! Published in 2022 at "Royal Society Open Science"
DOI: 10.1098/rsos.220125
Abstract: The post-translational modification of proteins expands the regulatory scope of the proteome far beyond what is achievable through genome regulation. The field of protein citrullination has seen significant progress in the last two decades. The… read more here.
Keywords: vices protein; citrullination; protein citrullination; biology ... See more keywords
PCSPred_SC: Prediction of Protein Citrullination Sites Using an Effective Sequence-Based Combined Method
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Access"
DOI: 10.1109/access.2020.2992672
Abstract: As one of post-translational modifications (PTMs), protein citrullination is crucial in a diverse array of cellular processes and implicated in a slew of human pathology. Therefore, accurate identification of protein citrullination sites (PCSs) is urgently… read more here.
Keywords: sequence based; citrullination sites; prediction; protein citrullination ... See more keywords
FRI0519 IDENTIFICATION OF CELLULAR TARGETS FOR ANTI-CITRULLINATED PROTEIN ANTIBODIES (ACPAS)
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.4179
Abstract: Background Autoantibodies against citrullinated proteins (ACPAs) have been suggested to play important roles in RA pathogenesis (1-3). Objectives In order to further dissect how ACPAs influence bone homeostasis and inflammation in the joints we analyzed… read more here.
Keywords: none declared; research support; microscopy; protein citrullination ... See more keywords