Targeting protein clearance pathways in GBA1-associated Parkinson disease
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2166828
Abstract: The clearance of damaged and unwanted proteins is essential for maintaining cellular homeostasis [1]. The two main mechanisms for the degradation of misfolded or aggregated proteins within the cell are the ubiquitin-proteasome system (UPS) and… read more here.
Keywords: clearance; gcase; parkinson disease; clearance pathways ... See more keywords
Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways
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DOI: 10.1371/journal.pone.0182895
Abstract: Impaired protein clearance likely increases the risk of protein accumulation disorders including Alzheimer’s disease (AD). Protein degradation through the proteasome pathway decreases with age and in AD brains, and the Aβ42 peptide has been shown… read more here.
Keywords: clearance pathways; protein clearance; activity; pathology ... See more keywords
Peritoneal Protein Clearance Is Associated With Cardiovascular Events but Not Mortality in Peritoneal Dialysis Patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.748934
Abstract: Introduction Association of peritoneal protein clearance (Pcl) with outcomes in patients with peritoneal dialysis (PD) is uncertain. Thus, we aimed to investigate its impact on cardiovascular events and all-cause mortality in patients with PD and… read more here.
Keywords: peritoneal dialysis; pcl; mortality; peritoneal protein ... See more keywords
Peritoneal Protein Clearance Is a Function of Local Inflammation and Membrane Area Whereas Systemic Inflammation and Comorbidity Predict Survival of Incident Peritoneal Dialysis Patients
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DOI: 10.3389/fphys.2019.00105
Abstract: It is not clear whether the association of increased peritoneal protein clearance (PPCl) with worse survival on peritoneal dialysis (PD) is a consequence of either local or systemic inflammation or indicative of generalized endothelial dysfunction… read more here.
Keywords: comorbidity; peritoneal protein; inflammation; protein clearance ... See more keywords
Relationships Between Peritoneal Protein Clearance and Parameters of Fluid Status Agree with Clinical Observations in Other Diseases that Venous Congestion Increases Microvascular Protein Escape
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DOI: 10.3747/pdi.2018.00016
Abstract: Background: Peritoneal effluent from peritoneal dialysis (PD) patients contains proteins, mainly transported from the circulation through large pores in the venular part of the peritoneal microvessels. Hydrostatic convection is the major driver for peritoneal protein… read more here.
Keywords: relationships peritoneal; peritoneal protein; venous congestion; protein clearance ... See more keywords