Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205573
Abstract: Polycomb repressive complex 1 (PRC1) is an essential epigenetic regulator that mainly controls histone H2A Lys119 mono-ubiquitination (H2AK119ub). BMI1 and RING1B are PRC1 core components and play critical roles in the development of various cancers.… read more here.
Keywords: bmi1 ring1b; protein complex; prc1; degradation ... See more keywords
Immuno‐detection of mRNA‐binding protein complex in human cells under transmission electron microscopy
Sign Up to like & getrecommendations! Published in 2019 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.23214
Abstract: Transit from the nuclear complex to the cytoplasm through the nuclear pore complex permits modification of mRNA, including processing such as splicing, capping, and polyadenylation, etc. At each of these events, mRNA interacts with various… read more here.
Keywords: protein complex; microscopy; electron microscopy; transmission electron ... See more keywords
An extracellular vesicular mutant KRAS‐associated protein complex promotes lung inflammation and tumor growth
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12307
Abstract: Abstract Extracellular vesicles (EVs) contain more than 100 proteins. Whether there are EVs proteins that act as an ‘organiser’ of protein networks to generate a new or different biological effect from that identified in EV‐producing… read more here.
Keywords: protein complex; inflammation; mutant kras; lung inflammation ... See more keywords
Protein complex finding and ranking: An application to Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biosciences"
DOI: 10.1007/s12038-017-9696-3
Abstract: Protein complexes are known to play a major role in controlling cellular activity in a living being. Identifying complexes from raw protein–protein interactions (PPIs) is an important area of research. Earlier work has been limited… read more here.
Keywords: protein; protein complex; alzheimer disease; protein complexes ... See more keywords
Precise Post-translational Tuning Occurs for Most Protein Complex Components during Meiosis
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.12.008
Abstract: Protein degradation is known to be a key component of expression regulation for individual genes, but its global impact on gene expression has been difficult to determine. We analyzed a parallel gene expression dataset of… read more here.
Keywords: protein; protein complex; translational tuning; post translational ... See more keywords
Dissecting the signaling features of the multi-protein complex GPCR/β-arrestin/ERK1/2.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of cell biology"
DOI: 10.1016/j.ejcb.2018.04.001
Abstract: G protein-coupled receptors (GPCRs) have emerged as key biological entities that regulate a plethora of physiological processes and participate in the onset and development of many diseases. Moreover, these receptors are important targets of almost… read more here.
Keywords: protein; protein complex; complex gpcr; features multi ... See more keywords
A Membrane Protein Complex Docking Benchmark.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.11.005
Abstract: We report the first membrane protein-protein docking benchmark consisting of 37 targets of diverse functions and folds. The structures were chosen based on a set of parameters such as the availability of unbound structures, the… read more here.
Keywords: protein; protein complex; docking benchmark; membrane protein ... See more keywords
Coat protein complex I facilitates dengue virus production.
Sign Up to like & getrecommendations! Published in 2018 at "Virus research"
DOI: 10.1016/j.virusres.2018.03.021
Abstract: Dengue hemorrhagic fever is a life-threatening disease caused by the dengue virus (DENV). After DENV enters into host cells, it replicates to generate viral particles to infect other cells. DENV exploits components of the cellular… read more here.
Keywords: protein; protein complex; production; denv ... See more keywords
Selective Removal of Unhydrolyzed Monolinked Peptides from Enriched Crosslinked Peptides To Improve the Coverage of Protein Complex Analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04927
Abstract: Chemical crosslinking combined with mass spectrometry (CXMS) has allowed the global characterization of protein complexes with high throughput and accuracy. Although enrichable crosslinkers have been introduced to exclude the interference of regular peptides, the crosslinked… read more here.
Keywords: protein complex; chemistry; complex analysis; monolinked peptides ... See more keywords
Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b00518
Abstract: Protein complexes often represent an ensemble of different assemblies with distinct functions and regulation. This increased complexity is enabled by the variety of protein diversification mechanisms that exist at every step of the protein biosynthesis… read more here.
Keywords: protein; protein complex; mass spectrometry; heterogeneity ... See more keywords
Anisotropic Friction in a Ligand-Protein Complex
Sign Up to like & getrecommendations! Published in 2023 at "Nano Letters"
DOI: 10.1021/acs.nanolett.2c04632
Abstract: The effect of an externally applied directional force on molecular friction is so far poorly understood. Here, we study the force-driven dissociation of the ligand-protein complex biotin-streptavidin and identify anisotropic friction as a not yet… read more here.
Keywords: protein complex; anisotropic friction; friction; ligand protein ... See more keywords