Sequence-based Prediction of the Cellular Toxicity Associated with Amyloid Aggregation within Protein Condensates
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00499
Abstract: Various neurological dysfunctions are associated with cytotoxic amyloid-containing aggregates formed through the irreversible maturation of protein condensates generated by phase separation. Here, we investigate the amino acid code for this cytotoxicity using TDP-43 deep-sequencing data.… read more here.
Keywords: based prediction; aggregation; sequence based; cytotoxicity ... See more keywords
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition
Sign Up to like & getrecommendations! Published in 2020 at "Nature Nanotechnology"
DOI: 10.1038/s41565-020-0731-4
Abstract: Membrane-less organelles resulting from liquid–liquid phase separation of biopolymers into intracellular condensates control essential biological functions, including messenger RNA processing, cell signalling and embryogenesis 1 – 4 . It has recently been discovered that several… read more here.
Keywords: solid transition; liquid solid; protein condensates; transition ... See more keywords