Synthesis of protein conjugates adsorbed on cationic liposomes surface
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DOI: 10.1016/j.mex.2020.100942
Abstract: The well-known Toll like receptor 9 (TLR9) agonist CpG ODN has shown promising results as vaccine adjuvant in preclinical and clinical studies, however its in vivo stability and potential systemic toxicity remain a concern. In… read more here.
Keywords: cpg odn; protein conjugates; chemistry; cationic liposomes ... See more keywords
Thermoresponsive polymer-peptide/protein conjugates
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DOI: 10.1016/j.progpolymsci.2016.12.004
Abstract: Abstract This review is focused on recent achievements in the covalent attachment of biological entities, such as oligopeptides, proteins and enzymes, to thermoresponsive synthetic polymers and the influence of conjugation on the properties of macromolecules.… read more here.
Keywords: thermoresponsive polymer; peptide protein; protein conjugates; polymer peptide ... See more keywords
Pyridine-2,6-dicarboxaldehyde-Enabled N-Terminal In Situ Growth of Polymer-Interferon α Conjugates with Significantly Improved Pharmacokinetics and In Vivo Bioactivity.
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DOI: 10.1021/acsami.0c15786
Abstract: Polymer-protein conjugates are a class of biohybrids with unique properties that are highly useful in biomedicine ranging from protein therapeutics to biomedical imaging; however, it remains a considerable challenge to conjugate polymers to proteins in… read more here.
Keywords: bioactivity; enabled terminal; protein conjugates; situ growth ... See more keywords