Synthesis of protein conjugates adsorbed on cationic liposomes surface
Sign Up to like & getrecommendations! Published in 2020 at "MethodsX"
DOI: 10.1016/j.mex.2020.100942
Abstract: The well-known Toll like receptor 9 (TLR9) agonist CpG ODN has shown promising results as vaccine adjuvant in preclinical and clinical studies, however its in vivo stability and potential systemic toxicity remain a concern. In… read more here.
Keywords: cpg odn; protein conjugates; chemistry; cationic liposomes ... See more keywords
Thermoresponsive polymer-peptide/protein conjugates
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Polymer Science"
DOI: 10.1016/j.progpolymsci.2016.12.004
Abstract: Abstract This review is focused on recent achievements in the covalent attachment of biological entities, such as oligopeptides, proteins and enzymes, to thermoresponsive synthetic polymers and the influence of conjugation on the properties of macromolecules.… read more here.
Keywords: thermoresponsive polymer; peptide protein; protein conjugates; polymer peptide ... See more keywords
Pyridine-2,6-dicarboxaldehyde-Enabled N-Terminal In Situ Growth of Polymer-Interferon α Conjugates with Significantly Improved Pharmacokinetics and In Vivo Bioactivity.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c15786
Abstract: Polymer-protein conjugates are a class of biohybrids with unique properties that are highly useful in biomedicine ranging from protein therapeutics to biomedical imaging; however, it remains a considerable challenge to conjugate polymers to proteins in… read more here.
Keywords: bioactivity; enabled terminal; protein conjugates; situ growth ... See more keywords
On-Demand Thio-Succinimide Hydrolysis for the Assembly of Stable Protein–Protein Conjugates
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c03721
Abstract: Chemical post-translational protein–protein conjugation is an important technique with growing applications in biotechnology and pharmaceutical research. Maleimides represent one of the most widely employed bioconjugation reagents. However, challenges associated with the instability of first- and… read more here.
Keywords: protein conjugates; succinimide hydrolysis; protein; protein protein ... See more keywords
HUH endonuclease-mediated DNA-protein conjugates: sequence-specific tools and cellular applications.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc04628a
Abstract: This highlight review article summarizes recent advances in employing HUH endonucleases as self-labeling protein tags for the sequence-specific covalent conjugation of unmodified ssDNA and examines their applications in cellular studies via engineered DNA-protein conjugates. We… read more here.
Keywords: protein conjugates; biology; protein; dna protein ... See more keywords