Structural motifs in protein cores and at protein–protein interfaces are different
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3996
Abstract: Structures of proteins and protein–protein complexes are determined by the same physical principles and thus share a number of similarities. At the same time, there could be differences because in order to function, proteins interact… read more here.
Keywords: protein; structural motifs; protein interfaces; protein protein ... See more keywords
Hysteresis and Allostery in Human UDP-Glucose Dehydrogenase Require a Flexible Protein Core.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00497
Abstract: Human UDP-glucose dehydrogenase (hUGDH) oxidizes UDP-glucose to UDP-glucuronic acid, an essential substrate in the phase II metabolism of drugs. The activity of hUGDH is regulated by the conformation of a buried allosteric switch (T131 loop/α6… read more here.
Keywords: state; udp glucose; hysteresis; protein core ... See more keywords
Polymer–Protein Core–Shell Nanoparticles for Enhanced Antigen Immunogenicity
Sign Up to like & getrecommendations! Published in 2017 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.7b00049
Abstract: Nanoengineered vaccine platforms can be modeled after viruses and other pathogens with highly organized and repetitive structures that trigger the host immune system. Here we demonstrated a pyridine-grafted poly(e-caprolactone)-based polymer–protein core–shell nanoparticles (PPCS-NPs) platform can… read more here.
Keywords: protein core; core shell; polymer protein; shell nanoparticles ... See more keywords