Particle Targeting in Complex Biological Media
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201700575
Abstract: Over the past few decades, nanoengineered particles have gained increasing interest for applications in the biomedical realm, including diagnosis, imaging, and therapy. When functionalized with targeting ligands, these particles have the potential to interact with… read more here.
Keywords: particle targeting; complex biological; biological media; protein corona ... See more keywords
Transforming Passive into Active: Multimodal Pheophytin-Based Carbon Dots Customize Protein Corona to Target Metastatic Breast Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202102270
Abstract: Formation of protein corona on nanomaterials surface in vivo is usually considered as an unpredictable event for a predefined targeted delivery system for malignant cancers. In most situations, these protein coronas substantially change targeting efficiency… read more here.
Keywords: cancer; breast cancer; carbon dots; protein corona ... See more keywords
Enhanced Competition at the Nano–Bio Interface Enables Comprehensive Characterization of Protein Corona Dynamics and Deep Coverage of Proteomes
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202206008
Abstract: Introducing engineered nanoparticles (NPs) into a biofluid such as blood plasma leads to the formation of a selective and reproducible protein corona at the particle–protein interface, driven by the relationship between protein–NP affinity and protein… read more here.
Keywords: enhanced competition; protein corona; interface; protein ... See more keywords
Fast and Dynamic Mapping of the Protein Corona on Nanoparticle Surfaces by Photocatalytic Proximity Labeling
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202206636
Abstract: Protein corona broadly affects the delivery of nanomedicines in vivo. Although it has been widely studied by multiple strategies like centrifugal sedimentation, the rapidly forming mechanism and the dynamic structure of the protein corona at… read more here.
Keywords: nano ppl; fast dynamic; photocatalytic proximity; proximity labeling ... See more keywords
Unraveling the Plasma Protein Corona by Ultrasonic Cavitation Augments Active‐Transporting of Liposome in Solid Tumor
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202207271
Abstract: Ligand/receptor‐mediated targeted drug delivery has been widely recognized as a promising strategy for improving the clinical efficacy of nanomedicines but is attenuated by the binding of plasma protein on the surface of nanoparticles to form… read more here.
Keywords: plasma protein; ultrasonic cavitation; tumor; protein corona ... See more keywords
Protein Corona: Prevention of Dominant IgG Adsorption on Nanocarriers in IgG‐Enriched Blood Plasma by Clusterin Precoating (Adv. Sci. 10/2019)
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201970062
Abstract: The development of nanocarriers for drug delivery is challenged by individual blood composition fluctuations. In article number 1802199, Svenja Morsbach and co‐workers report the accumulation of immunoglobulins in the protein corona of nanocarriers in IgG‐enriched… read more here.
Keywords: protein corona; blood; enriched blood; nanocarriers igg ... See more keywords
Phosphonylation Controls the Protein Corona of Multifunctional Polyglycerol-Modified Nanocarriers.
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201800468
Abstract: Nanocarriers are a platform for modern drug delivery. In contact with blood, proteins adsorb to nanocarriers, altering their behavior in vivo. To reduce unspecific protein adsorption and unspecific cellular uptake, nanocarriers are modified with hydrophilic… read more here.
Keywords: polyglycerol; corona multifunctional; controls protein; multifunctional polyglycerol ... See more keywords
Effect of Core-Crosslinking on Protein Corona Formation on Polymeric Micelles.
Sign Up to like & getrecommendations! Published in 2021 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202000414
Abstract: Most nanomaterials acquire a protein corona upon contact with biological fluids. The magnitude of this effect is strongly dependent both on surface and structure of the nanoparticle. To define the contribution of the internal nanoparticle… read more here.
Keywords: core crosslinking; corona formation; protein corona; plasma proteins ... See more keywords
Squaric Ester-Based Nanogels Induce No Distinct Protein Corona but Entrap Plasma Proteins into their Porous Hydrogel Network.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200318
Abstract: After intravenous administration of nanocarriers, plasma proteins may rapidly adsorb onto their surface. This process hampers the prediction of the nanocarriers' pharmacokinetics as it determines their physiological identity in a complex biological environment. Towards clinical… read more here.
Keywords: squaric ester; network; plasma proteins; ester based ... See more keywords
Protein Corona: Impact of Lymph Versus Blood in a Complex In Vitro Environment.
Sign Up to like & getrecommendations! Published in 2017 at "Small"
DOI: 10.1002/smll.201700409
Abstract: In biological environments, the surface of nanoparticles (NPs) are modified by protein corona (PC) that determines their biological behavior. Unfortunately, in vitro tests still give different PC than in vivo tests causing in vitro-in vivo… read more here.
Keywords: corona impact; impact lymph; vivo; blood ... See more keywords
Beyond Global Charge: Role of Amine Bulkiness and Protein Fingerprint on Nanoparticle-Cell Interaction.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201802088
Abstract: Amino groups presented on the surface of nanoparticles are well-known to be a predominant factor in the formation of the protein corona and subsequent cellular uptake. However, the molecular mechanism underpinning this relationship is poorly… read more here.
Keywords: protein; amine bulkiness; association; protein corona ... See more keywords