Illuminating G-Protein-Coupling Selectivity of GPCRs
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.04.044
Abstract: Heterotrimetic G proteins consist of four subfamilies (Gs, Gi/o, Gq/11, and G12/13) that mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding Gα C termini. G-protein-coupling profiles govern GPCR-induced cellular responses, yet receptor sequence… read more here.
Keywords: illuminating protein; protein coupling; coupling selectivity; gpcrs ... See more keywords
Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.09.26.509559
Abstract: The formation of neural circuits requires extensive interactions of cell-surface proteins to guide axons to their correct target neurons. Trans-cellular interactions of the adhesion G protein-coupled receptor latrophilin-2 (Lphn2) with its partner teneurin-3 instruct the… read more here.
Keywords: lphn2; tethered agonist; protein coupling; context dependent ... See more keywords
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abf1268
Abstract: Structures of prostaglandin receptor EP2 revealed its agonists’ selectivity and G protein coupling mechanism. Selective modulation of the heterotrimeric G protein α S subunit–coupled prostaglandin E2 (PGE2) receptor EP2 subtype is a promising therapeutic strategy… read more here.
Keywords: ep2; receptor ep2; protein coupling; activation ... See more keywords
Constitutive G protein coupling profiles of understudied orphan GPCRs
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DOI: 10.1371/journal.pone.0247743
Abstract: A large number of GPCRs are potentially valuable drug targets but remain understudied. Many of these lack well-validated activating ligands and are considered “orphan” receptors, and G protein coupling profiles have not been defined for… read more here.
Keywords: protein; coupling profiles; orphan gpcrs; understudied orphan ... See more keywords
The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.868579
Abstract: The chemokine receptor CXCR3 plays a critical role in immune cell recruitment and activation. CXCR3 exists as two main isoforms, CXCR3-A and CXCR3-B, resulting from alternative splicing. Although the two isoforms differ only by the… read more here.
Keywords: chemokine; extended terminal; chemokine receptor; cxcr3 ... See more keywords