DNA-protein cross-links: Formidable challenges to maintaining genome integrity.
Sign Up to like & getrecommendations! Published in 2018 at "DNA repair"
DOI: 10.1016/j.dnarep.2018.08.024
Abstract: DNA is associated with proteins that are involved in its folding and transaction processes. When cells are exposed to chemical cross-linking agents or free radical-generating ionizing radiation, DNA-associated proteins are covalently trapped within the DNA… read more here.
Keywords: cross links; dpcs; dna; protein cross ... See more keywords
Quantification of a Novel DNA-Protein Cross-Link Product Formed by Reacting Apurinic/Apyrimidinic Sites in DNA with Cysteine Residues in Protein by Liquid Chromatography-Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b04306
Abstract: Emerging evidence suggests that cross-links formed by reacting DNA lesions with proteins may play a significant role in the pathophysiology of human cancer and degenerative diseases. The goal of this study was to develop a… read more here.
Keywords: protein cross; dna protein; method; cross ... See more keywords
Amyloid Protein Cross-Seeding Provides a New Perspective on Multiple Diseases In Vivo.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c01233
Abstract: Amyloid protein cross-seeding is a peculiar phenomenon of cross-spreading among different diseases. Unlike traditional infectious ones, diseases caused by amyloid protein cross-seeding are spread by misfolded proteins instead of pathogens. As a consequence of the… read more here.
Keywords: new perspective; amyloid protein; cross; cross seeding ... See more keywords
Proxl (Protein Cross-Linking Database): A Public Server, QC Tools, and Other Major Updates.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.8b00726
Abstract: Proxl is an open-source web application for sharing, visualizing, and analyzing bottom-up protein cross-linking mass spectrometry data and results. Proxl's core features include comparing data sets, structural analysis, customizable and interactive data visualizations, access to… read more here.
Keywords: proxl protein; protein cross; cross; cross linking ... See more keywords
Prediction of an Upper Limit for the Fraction of Inter-Protein Cross-Links in Large-scale In Vivo Cross-Linking Studies.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00189
Abstract: Chemical cross-linking and mass spectrometry is of growing use for establishment of distance constraints on protein conformations and interactions. Whereas intra-protein cross-links can arise from proteins in isolation, inter-protein cross-links reflect proximity of two interacting… read more here.
Keywords: protein; cross links; protein cross; inter protein ... See more keywords
5-Formylcytosine mediated DNA–protein cross-links block DNA replication and induce mutations in human cells
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky809
Abstract: There was a typographical error on page 6458, column 1, line 12 and on page 6459, column 2, line 53. In both instances, dNTP concentrations should be listed as ‘5, 10, 25, 50, 100, 150,… read more here.
Keywords: cross links; links block; protein cross; dna protein ... See more keywords
Resolving a DNA-protein cross-link
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.357.6358.1366-m
Abstract: DNA Repair Topoisomerase 2 (TOP2) creates DNA double-strand breaks to regulate DNA topology and is critical for processes such as replication and transcription. A covalent complex between TOP2 and DNA (TOP2cc) is an intermediate in… read more here.
Keywords: resolving dna; dna; protein cross; dna protein ... See more keywords