The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2019.12.067
Abstract: SUMMARY DNA-protein crosslinks (DPCs) are a frequent form of DNA lesion and are strongly inhibitive in diverse DNA transactions. Despite recent developments, the biochemical detection of DPCs remains a limiting factor for the in-depth mechanistic… read more here.
Keywords: protein crosslinks; detection; dna; sensitive versatile ... See more keywords
Biomimetic mimicry of formaldehyde-induced DNA–protein crosslinks in the confined space of a metal–organic framework
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc00188h
Abstract: DNA–protein crosslinks (DPCs) are highly toxic DNA lesions induced by crosslinking agents such as formaldehyde (HCHO). Building artificial models to simulate the crosslinking process would advance our understanding of the underlying mechanisms and therefore develop… read more here.
Keywords: protein crosslinks; organic framework; dna protein; metal organic ... See more keywords
DNA-Protein Crosslinks and Their Resolution.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of biochemistry"
DOI: 10.1146/annurev-biochem-032620-105820
Abstract: Covalent DNA-protein crosslinks (DPCs) are pervasive DNA lesions that interfere with essential chromatin processes such as transcription or replication. This review strives to provide an overview of the sources and principles of cellular DPC formation.… read more here.
Keywords: dna protein; dna; crosslinks resolution; protein crosslinks ... See more keywords
Stimulation of Replication Template-Switching by DNA-Protein Crosslinks
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.3390/genes10010014
Abstract: Covalent DNA protein crosslinks (DPCs) are common lesions that block replication. We examine here the consequence of DPCs on mutagenesis involving replicational template-switch reactions in Escherichia coli. 5-Azacytidine (5-azaC) is a potent mutagen for template-switching.… read more here.
Keywords: protein crosslinks; template switching; dna; dna protein ... See more keywords