Hsp70 – a master regulator in protein degradation
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12751
Abstract: Proteostasis, the controlled balance of protein synthesis, folding, assembly, trafficking and degradation, is a paramount necessity for cell homeostasis. Impaired proteostasis is a hallmark of ageing and of many human diseases. Molecular chaperones are essential… read more here.
Keywords: protein; degradation; hsp70 master; protein degradation ... See more keywords
Genetic manipulation and targeted protein degradation in mammalian systems: practical considerations, tips and tricks for discovery research.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13581
Abstract: Gaining a mechanistic understanding of the molecular pathways underpinning cellular and organismal physiology invariably relies on perturbation of an experimental system to infer causality. This can be achieved either by genetic manipulation or by pharmacological… read more here.
Keywords: mammalian systems; genetic manipulation; targeted protein; manipulation ... See more keywords
PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery
Sign Up to like & getrecommendations! Published in 2018 at "BioEssays"
DOI: 10.1002/bies.201700247
Abstract: Proteolysis‐targeting chimeric molecules (PROTACs) represent an emerging technique that is receiving much attention for therapeutic intervention. The mechanism is based on the inhibition of protein function by hijacking a ubiquitin E3 ligase for protein degradation.… read more here.
Keywords: protein; technique; degradation; protein degradation ... See more keywords
Multifaceted targeted protein degradation systems for different cellular compartments
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200008
Abstract: Selective protein degradation maintains cellular homeostasis, but this process is disrupted in many diseases. Targeted protein degradation (TPD) approaches, built upon existing cellular mechanisms, are promising methods for therapeutically regulating protein levels. Here, we review… read more here.
Keywords: cellular compartments; targeting chimeras; protein degradation; targeted protein ... See more keywords
Repurposing a DNA‐Repair Enzyme for Targeted Protein Degradation
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200053
Abstract: Herein we present the exploration of the utility of DNA demethylase enzymes for targeted protein degradation. Novel benzylguanine substrates are characterized for their ability to control protein degradation in cells. Our data demonstrate the utility… read more here.
Keywords: dna repair; repurposing dna; targeted protein; protein degradation ... See more keywords
NFκB2 p52 stabilizes rhogdiβ mRNA by inhibiting AUF1 protein degradation via a miR‐145/Sp1/USP8‐dependent axis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22970
Abstract: Although overexpression of the non‐canonical NFκB subunit p52 has been observed in several tumors, the function and mechanism of p52 in bladder cancer (BC) are less well understood. Here, we aimed at understanding the role… read more here.
Keywords: invasion; rhogdi mrna; protein degradation; auf1 protein ... See more keywords
Norcantharidin promotes cancer radiosensitization through Cullin1 neddylation‐mediated CDC6 protein degradation
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23435
Abstract: Radiotherapy (RT) is a conventional cancer therapeutic modality. However, cancer cells tend to develop radioresistance after a period of treatment. Diagnostic markers and therapeutic targets for radiosensitivity are severely lacking. Our recently published studies demonstrated… read more here.
Keywords: cancer; protein degradation; cdc6 protein; protein ... See more keywords
Can We Treat Neurodegenerative Proteinopathies by Enhancing Protein Degradation?
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29058
Abstract: Neurodegenerative proteinopathies are defined as a class of neurodegenerative disorders, with either genetic or sporadic age‐related onset, characterized by the pathological accumulation of aggregated protein deposits. These mainly include Alzheimer's disease (AD), Parkinson's disease (PD),… read more here.
Keywords: neurodegenerative proteinopathies; disease; protein degradation; treat neurodegenerative ... See more keywords
Targeted Protein Degradation Technology and Nanomedicine: Powerful Allies against Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207778
Abstract: Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential of targeting undruggable pathogenic proteins. After the first proof-of-concept proteolysis-targeting chimeric (PROTAC) molecule was reported, the TPD field has entered a new era. In… read more here.
Keywords: tpd; targeted protein; degradation technology; protein degradation ... See more keywords
Coordinated Actions Between p97 and Cullin-RING Ubiquitin Ligases for Protein Degradation.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_5
Abstract: The cullin-RING ubiquitin ligases comprise the largest subfamily of ubiquitin ligases. They control ubiquitylation and degradation of a large number of protein substrates in eukaryotes. p97 is an ATPase domain-containing protein segregase. It plays essential… read more here.
Keywords: cullin ring; ring ubiquitin; ubiquitin ligases; coordinated actions ... See more keywords
Mechanistic insights into ER-associated protein degradation.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2018.04.004
Abstract: Misfolded proteins of the endoplasmic reticulum (ER) are discarded by a conserved process, called ER-associated protein degradation (ERAD). ERAD substrates are retro-translocated into the cytosol, polyubiquitinated, extracted from the ER membrane, and ultimately degraded by… read more here.
Keywords: associated protein; insights associated; erad; protein degradation ... See more keywords