A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15719-6
Abstract: Although cellular senescence acts primarily as a tumour suppression mechanism, the accumulation of senescent cells in vivo eventually exerts deleterious side effects through inflammatory/tumour-promoting factor secretion. Thus, the development of new drugs that cause the… read more here.
Keywords: senescent cells; family protein; provokes senolysis; protein degrader ... See more keywords
Translational PK-PD for targeted protein degradation.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d2cs00114d
Abstract: Targeted protein degradation has emerged from the chemical biology toolbox as one of the most exciting areas for novel therapeutic development across the pharmaceutical industry. The ability to induce the degradation, and not just inhibition,… read more here.
Keywords: protein degrader; pharmacology; targeted protein; protein degradation ... See more keywords
UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169094
Abstract: We previously reported that glucokinase is ubiquitinated and degraded by cereblon with an unknown endogenous glucokinase protein degrader. Here, we show that UDP-glucose is a glucokinase protein degrader. We identified that both glucose and UDP-glucose… read more here.
Keywords: cereblon; protein degrader; udp glucose; glucokinase ... See more keywords