l-Serine-Mediated Neuroprotection Includes the Upregulation of the ER Stress Chaperone Protein Disulfide Isomerase (PDI)
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9817-7
Abstract: The unfolded protein response (UPR) is a highly evolutionarily conserved response to endoplasmic reticulum (ER) stress, which functions to return cells to homeostasis or send them into apoptosis, depending on the degree of cellular damage.… read more here.
Keywords: protein; disulfide isomerase; serine; protein disulfide ... See more keywords
Protein disulfide isomerases: Redox connections in and out of the endoplasmic reticulum.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2016.11.007
Abstract: Protein disulfide isomerases are thiol oxidoreductase chaperones from thioredoxin superfamily. As redox folding catalysts from the endoplasmic reticulum (ER), their roles in ER-related redox homeostasis and signaling are well-studied. PDIA1 exerts thiol oxidation/reduction and isomerization,… read more here.
Keywords: protein disulfide; disulfide isomerases; endoplasmic reticulum;
Identification of amphioxus protein disulfide isomerase as both an enzyme and an immunocompotent factor.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104238
Abstract: Previous studies have shown that protein disulfide isomerase (PDI), a member of the thioredoxin (TRX) superfamily, are broadly associated in immune responses in a variety of animals. However, it remains largely unknown about the direct… read more here.
Keywords: immunocompotent factor; disulfide isomerase; protein disulfide; isomerase ... See more keywords
Protein Disulfide Isomerase increases Nox1 activation through EGFR signaling in hypertension
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.302
Abstract: We have previously shown that expression of protein disulfide isomerase (PDI) and Nox1 in resistance arteries correlates with the development of hypertension. Epidermal growth factor (EGF)-like ligands are increased in vascular disease and their levels… read more here.
Keywords: disulfide isomerase; protein disulfide; expression; hypertension ... See more keywords
Inhibition of protein disulfide isomerase has neuroprotective effects in a mouse model of experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106286
Abstract: Endoplasmic reticulum (ER) stress is strictly linked to neuroinflammation and involves in the development of neurodegenerative disorders. Protein disulfide isomerase (PDI) is an enzyme that catalyzes formation and isomerization of disulfide bonds and also acts… read more here.
Keywords: disulfide isomerase; protein disulfide; stress; autoimmune encephalomyelitis ... See more keywords
Differential expression of protein disulfide isomerase (PDI) in regulating endometrial receptivity in humans.
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive biology"
DOI: 10.1016/j.repbio.2021.100498
Abstract: Estrogen and progesterone regulate the expression of endometrial proteins that determine endometrial receptivity for embryo implantation. The protein disulfide isomerase (PDI) family of proteins play a diverse role in regulating protein modification and redox function.… read more here.
Keywords: receptivity; protein disulfide; regulating endometrial; role ... See more keywords
Flavonoids as Protein Disulfide Isomerase Inhibitors: Key Molecular and Structural Features for the Interaction.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07994
Abstract: Quercetin-3-rutinoside (rutin) is a bioflavonoid that is common in foods. The finding that quercetin-3-rutinoside inhibits protein disulfide isomerase (PDI) and potently blocks thrombosis in vivo has enabled the evaluation of PDI inhibition in multiple animal… read more here.
Keywords: pdi; protein disulfide; activity; quercetin rutinoside ... See more keywords
The Hydroxyproline Proteome of HeLa cells with Emphasis on the Active Sites of Protein Disulfide Isomerases.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00625
Abstract: Hydroxyproline-containing proteins (other than collagens) are rare and difficult to identify. Only 14 such proteins have been found in the human proteome by biochemical methods, despite the fact that the list includes examples of biological… read more here.
Keywords: protein; hydroxyproline proteome; pdia4; protein disulfide ... See more keywords
Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-19429-4
Abstract: A Disintegrin and Metalloprotease 17 (ADAM17) can cause the fast release of growth factors and inflammatory mediators from the cell surface. Its activity has to be turned on which occurs by various stimuli. The active… read more here.
Keywords: disintegrin metalloprotease; disulfide switch; switch; disulfide isomerases ... See more keywords
Orally delivered rutin in lipid-based nano-formulation exerts strong antithrombotic effects by protein disulfide isomerase inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2083726
Abstract: Abstract Thrombosis occurs in both macrovasculature and microvasculature, causing various cardio-cerebral vascular diseases. The lack of effective and safe antithrombotic drugs leads to a public health crisis. Mounting evidence suggests that protein disulfide isomerase (PDI)… read more here.
Keywords: protein disulfide; based nano; lipid based; disulfide isomerase ... See more keywords
Formation of Protein Disulfide Bonds Catalyzed by OsPDIL1;1 is Mediated by MicroRNA5144-3p in Rice
Sign Up to like & getrecommendations! Published in 2018 at "Plant and Cell Physiology"
DOI: 10.1093/pcp/pcx189
Abstract: Correct folding of proteins in the endoplasmic reticulum is important for their stability and function under stress. The protein disulfide isomerase (PDI) OsPDIL1;1 is a key protein-folding catalyst in rice (Oryza sativa L.). Here, microRNA5144… read more here.
Keywords: rice; formation; protein disulfide; stress ... See more keywords