Protein WW domain denaturation on defective graphene reveals the significance of nanomaterial defects in nanotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "Carbon"
DOI: 10.1016/j.carbon.2019.01.107
Abstract: Abstract Nanomaterial defects occur widely due to various situations such as synthesis imperfections, exposure to harsh environment, or even intentional designs. However, the consequence of nanomaterial defects on their interfacing biological systems remains largely unknown.… read more here.
Keywords: nanomaterial defects; graphene; defective graphene; protein domain ... See more keywords
Insights into the immune manipulation mechanisms of pollen allergens by protein domain profiling
Sign Up to like & getrecommendations! Published in 2017 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2017.07.006
Abstract: Plant pollens are airborne allergens, as their inhalation causes immune activation, leading to rhinitis, conjunctivitis, sinusitis and oral allergy syndrome. A myriad of pollen proteins belonging to profilin, expansin, polygalacturonase, glucan endoglucosidase, pectin esterase, and… read more here.
Keywords: immune manipulation; protein domain; insights immune; immune system ... See more keywords
Protein Domain Microarrays as a Platform to Decipher Signaling Pathways and the Histone Code.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.08.007
Abstract: Signal transduction is driven by protein interactions that are controlled by posttranslational modifications (PTM). Usually, protein domains are responsible for "reading" the PTM signal deposited on the interacting partners. Protein domain microarrays have been developed… read more here.
Keywords: protein; platform decipher; protein domain; protein interactions ... See more keywords
DEPCOD: a tool to detect and visualize co-evolution of protein domains
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac349
Abstract: Abstract Proteins with similar phylogenetic patterns of conservation or loss across evolutionary taxa are strong candidates to work in the same cellular pathways or engage in physical or functional interactions. Our previously published tools implemented… read more here.
Keywords: depcod tool; tool detect; protein domains; protein domain ... See more keywords
Multi-head attention-based U-Nets for predicting protein domain boundaries using 1D sequence features and 2D distance maps
Sign Up to like & getrecommendations! Published in 2022 at "BMC Bioinformatics"
DOI: 10.1101/2022.04.08.487689
Abstract: The information about the domain architecture of proteins is useful for studying protein structure and function. However, accurate prediction of protein domain boundaries (i.e., sequence regions separating two domains) from sequence remains a significant challenge.… read more here.
Keywords: multi head; sequence; domain; protein domain ... See more keywords
DeepDom: Predicting protein domain boundary from sequence alone using stacked bidirectional
Sign Up to like & getrecommendations! Published in 2019 at "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing"
DOI: 10.1142/9789813279827_0007
Abstract: Protein domain boundary prediction is usually an early step to understand protein function and structure. Most of the current computational domain boundary prediction methods suffer from low accuracy and limitation in handling multi-domain types, or… read more here.
Keywords: protein; protein domain; domain boundary; using stacked ... See more keywords
Method for Identifying Essential Proteins by Key Features of Proteins in a Novel Protein-Domain Network
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.708162
Abstract: In recent years, due to low accuracy and high costs of traditional biological experiments, more and more computational models have been proposed successively to infer potential essential proteins. In this paper, a novel prediction method… read more here.
Keywords: novel protein; domain network; essential proteins; protein domain ... See more keywords
Zika Virus Envelope Protein Domain III Produced in K. phaffii Has the Potential for Diagnostic Applications
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12051198
Abstract: Zika virus (ZIKV) represents a global human health threat and it is related to severe diseases such as congenital Zika syndrome (CZS) and Guillain-Barré syndrome (GBS). There is no vaccine available nor specific antiviral treatment,… read more here.
Keywords: virus envelope; diagnostic applications; envelope protein; protein domain ... See more keywords