Multivalent Display Using Hybrid Virus Nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7893-9_10
Abstract: Many important biological interactions are multivalent and often sensitive to spatial organization. Nonenveloped viruses are a natural source of scaffolds for building multivalent ligands to probe these types of interactions which avoid complex synthetic schemes… read more here.
Keywords: protein; using hybrid; protein domains; multivalent display ... See more keywords
High-Throughput Isolation of Soluble Protein Domains Using a Bipartite Split-GFP Complementation System.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9624-7_15
Abstract: The identification of soluble, folded domains of proteins is a recurring task in modern molecular biology. We detail a protocol for identifying compact soluble protein domains using a self-assembling two-part split-GFP comprised of a detector… read more here.
Keywords: protein; split gfp; soluble protein; domains using ... See more keywords
dSPRINT: predicting DNA, RNA, ion, peptide and small molecule interaction sites within protein domains
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab356
Abstract: Abstract Domains are instrumental in facilitating protein interactions with DNA, RNA, small molecules, ions and peptides. Identifying ligand-binding domains within sequences is a critical step in protein function annotation, and the ligand-binding properties of proteins… read more here.
Keywords: protein; ligand binding; protein domains; dna rna ... See more keywords
DEPCOD: a tool to detect and visualize co-evolution of protein domains
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac349
Abstract: Abstract Proteins with similar phylogenetic patterns of conservation or loss across evolutionary taxa are strong candidates to work in the same cellular pathways or engage in physical or functional interactions. Our previously published tools implemented… read more here.
Keywords: depcod tool; tool detect; protein domains; protein domain ... See more keywords
Pathway-specific protein domains are predictive for human diseases
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1007052
Abstract: Protein domains are basic functional units of proteins. Many protein domains are pervasive among diverse biological processes, yet some are associated with specific pathways. Human complex diseases are generally viewed as pathway-level disorders. Therefore, we… read more here.
Keywords: protein; pathway specific; specific domains; protein domains ... See more keywords
Widespread evolutionary crosstalk among protein domains in the context of multi-domain proteins
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0203085
Abstract: Domains are distinct units within proteins that typically can fold independently into recognizable three-dimensional structures to facilitate their functions. The structural and functional independence of protein domains is reflected by their apparent modularity in the… read more here.
Keywords: context multi; domain proteins; protein domains; multi domain ... See more keywords
Persistence of Functional Protein Domains in Mycoplasma Species and their Role in Host Specificity and Synthetic Minimal Life
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2017.00031
Abstract: Mycoplasmas are the smallest self-replicating organisms and obligate parasites of a specific vertebrate host. An in-depth analysis of the functional capabilities of mycoplasma species is fundamental to understand how some of simplest forms of life… read more here.
Keywords: mycoplasma species; protein domains; minimal life; host ... See more keywords
On the Effects of Disordered Tails, Supertertiary Structure and Quinary Interactions on the Folding and Function of Protein Domains
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12020209
Abstract: The vast majority of our current knowledge about the biochemical and biophysical properties of proteins derives from in vitro studies conducted on isolated globular domains. However, a very large fraction of the proteins expressed in… read more here.
Keywords: function; structure; disordered tails; folding function ... See more keywords
Neural Networks in the Design of Molecules with Affinity to Selected Protein Domains
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021762
Abstract: Drug design with machine learning support can speed up new drug discoveries. While current databases of known compounds are smaller in magnitude (approximately 108), the number of small drug-like molecules is estimated to be between… read more here.
Keywords: affinity selected; protein domains; selected protein; drug ... See more keywords