Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.05.028
Abstract: Small molecule covalent drugs provide desirable therapeutic properties over noncovalent ones for treating challenging diseases. The potential of covalent protein drugs, however, remains unexplored due to protein's inability to bind targets covalently. We report a… read more here.
Keywords: protein; covalent protein; protein drugs; proximity enabled ... See more keywords
Tannic Acid-Assisted Biomineralization Strategy for Encapsulation and Intracellular Delivery of Protein Drugs.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c15205
Abstract: Protein therapy has been considered to be one of the most direct and safe ways to regulate cell function and treat tumors. However, safe and effective intracellular delivery of protein drugs is still a key… read more here.
Keywords: delivery protein; protein drugs; therapy; intracellular delivery ... See more keywords
Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26367-9
Abstract: Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. Here we report the development of a Salmonella-based intracellular delivery system to address this challenge. We engineer genetic circuits that (1)… read more here.
Keywords: protein drugs; system; delivery; intracellular delivery ... See more keywords
Dynamic-responsive virus-mimetic nanocapsules facilitate protein drug penetration and extracellular-specific unpacking for antitumor treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00500j
Abstract: Protein-based drugs have been demonstrating great potential for the treatment of various diseases, but most of them encounter many difficulties in clinical trials or uses, such as instability, low bioavailability, and poor in vivo efficacy.… read more here.
Keywords: virus mimetic; mimetic nanocapsules; protein drugs; treatment ... See more keywords
The Stability Maintenance of Protein Drugs in Organic Coatings Based on Nanogels
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12020115
Abstract: Protein drugs are often loaded on scaffolds with organic coatings to realize a spatiotemporal controlled release. The stability or activity of protein drugs, however, is largely affected by the organic coating, particularly with organic solvents,… read more here.
Keywords: protein; protein drugs; drugs organic; organic coatings ... See more keywords