NIPSNAP protein family emerges as a sensor of mitochondrial health
Sign Up to like & getrecommendations! Published in 2021 at "BioEssays"
DOI: 10.1002/bies.202100014
Abstract: Since their discovery over two decades ago, the molecular and cellular functions of the NIPSNAP family of proteins (NIPSNAPs) have remained elusive until recently. NIPSNAPs interact with a variety of mitochondrial and cytoplasmic proteins. They… read more here.
Keywords: nipsnap protein; mitochondrial health; protein family; health ... See more keywords
Bacillus thuringiensis Vegetative Insecticidal Protein Family Vip3A and Mode of Action against Pest Lepidopteran.
Sign Up to like & getrecommendations! Published in 2020 at "Pest management science"
DOI: 10.1002/ps.5804
Abstract: Vip3A proteins are widely used for controlling pest Lepidoptera. Different binding sites with different receptors in the insect midgut membrane and lack of cross-resistance with Cry proteins enhance their applicability, as both single proteins and… read more here.
Keywords: insecticidal; vip3a; vip3a proteins; protein family ... See more keywords
The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.01.011
Abstract: TIA1 and TIAL1 encode a family of U-rich element mRNA-binding proteins ubiquitously expressed and conserved in metazoans. Using PAR-CLIP, we determined that both proteins bind target sites with identical specificity in 3' UTRs and introns… read more here.
Keywords: protein family; cell cycle; family; stress ... See more keywords
Protein Family-Specific Models Using Deep Neural Networks and Transfer Learning Improve Virtual Screening and Highlight the Need for More Data
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00350
Abstract: Machine learning has shown enormous potential for computer-aided drug discovery. Here we show how modern convolutional neural networks (CNNs) can be applied to structure-based virtual screening. We have coupled our densely connected CNN (DenseNet) with… read more here.
Keywords: virtual screening; transfer learning; neural networks; protein family ... See more keywords
Coevolved Positions Represent Key Functional Properties in the Trypsin-Like Serine Proteases Protein Family
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00903
Abstract: Trypsin-like Serine Proteases are a group of homologous enzymes which exert multiple roles in both vertebrate and invertebrate organisms. Key properties of these enzymes include their activation from an inactive zymogen form to their active… read more here.
Keywords: trypsin like; like serine; serine proteases; protein family ... See more keywords
Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2016.341
Abstract: Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia read more here.
Keywords: bcl protein; protein family; pattern determines; family expression ... See more keywords
Genetic variants affecting equivalent protein family positions reflect human diversity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12971-7
Abstract: Members of diverse protein families often perform overlapping or redundant functions meaning that different variations within them could reflect differences between individual organisms. We investigated likely functional positions within aligned protein families that contained a… read more here.
Keywords: equivalent protein; variants affecting; genetic variants; protein family ... See more keywords
Prognostic value of the S100 calcium binding protein family members in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Bioscience reports"
DOI: 10.1042/bsr20222523
Abstract: Hepatocellular carcinoma (HCC) remains a crucial public health problem around the world, and the outlook remains bleak. More accurate prediction models are urgently needed because of the great heterogeneity of HCC. The S100 protein family contains over… read more here.
Keywords: hepatocellular carcinoma; family; family members; s100 family ... See more keywords
A member of the CONSTANS-Like protein family is a putative regulator of reactive oxygen species homeostasis and spaceflight physiological adaptation
Sign Up to like & getrecommendations! Published in 2019 at "AoB Plants"
DOI: 10.1093/aobpla/ply075
Abstract: Abstract A feature of the physiological adaptation to spaceflight in Arabidopsis thaliana (Arabidopsis) is the induction of reactive oxygen species (ROS)-associated gene expression. The patterns of ROS-associated gene expression vary among Arabidopsis ecotypes, and the… read more here.
Keywords: protein family; physiological adaptation; member; adaptation ... See more keywords
RefSeq: expanding the Prokaryotic Genome Annotation Pipeline reach with protein family model curation
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkaa1105
Abstract: The Reference Sequence (RefSeq) project at the National Center for Biotechnology Information (NCBI) contains nearly 200 000 bacterial and archaeal genomes and 150 million proteins with up-to-date annotation. Changes in the Prokaryotic Genome Annotation Pipeline… read more here.
Keywords: refseq; protein family; annotation; prokaryotic genome ... See more keywords
Heat shock protein family A member 6 combined with clinical characteristics for the differential diagnosis of intestinal Behçet’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Digestive Diseases"
DOI: 10.1111/1751-2980.12613
Abstract: To investigate the role of heat shock protein family A member 6 (HSPA6) expression alone and in combination with clinical characteristics in distinguishing intestinal Behçet’s disease (BD) from Crohn’s disease (CD) with ileocolonic involvement. read more here.
Keywords: family member; protein family; disease; heat shock ... See more keywords