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   Articles with "protein fap" as a keyword



Synthesis and Preclinical Evaluation of Druglike 18F-Labeled Fibroblast Activation Protein (FAP) Inhibitors with Enhanced Tumor Retention.

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recommendations! Published in 2025 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.5c00366

Abstract: Fibroblast activation protein (FAP) is upregulated in cancer and fibrosis, making it an ideal target for imaging and therapy. Most FAP radioligands are large, highly polar, chelator-based molecules that suffer from limited tissue penetration and… read more here.

Keywords: fibroblast activation; protein fap; tumor retention; tumor ... See more keywords

Structure-Property Investigation of New "KetoFAPI" Inhibitors of Fibroblast Activation Protein (FAP): Discovery of Highly Potent, Selective Compounds with Prolonged Residence Times and Promising Radiotheranostic Potential.

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recommendations! Published in 2025 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.5c02102

Abstract: Fibroblast activation protein α (FAP) is a serine protease that has emerged as an attractive, pan-cancer radiotheranostic target. The development of effective FAP-targeting radiotheranostics critically relies on the identification of FAP inhibitors that achieve prolonged… read more here.

Keywords: potent selective; highly potent; fibroblast activation; protein fap ... See more keywords

Fibroblast activation protein (FAP) as a prognostic biomarker in multiple tumors and its therapeutic potential in head and neck squamous cell carcinoma

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recommendations! Published in 2024 at "Oncology Research"

DOI: 10.32604/or.2024.046965

Abstract: Background Fibroblast activation protein (FAP), a cell surface serine protease, plays roles in tumor invasion and immune regulation. However, there is currently no pan-cancer analysis of FAP. Objective: We aimed to assess the pan-cancer expression… read more here.

Keywords: fibroblast activation; protein fap; cell; tumor ... See more keywords

Radioligands Targeting Fibroblast Activation Protein (FAP)

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recommendations! Published in 2021 at "Cancers"

DOI: 10.3390/cancers13225744

Abstract: Simple Summary FAP-targeted radiotracers, recently introduced in cancer treatment, accumulate in Cancer-Associated Fibroblasts (CAFs). CAFs are present in tumor lesions but do not correspond to genuine cancer cells, although they behave in an abnormal and… read more here.

Keywords: medicine; nuclear medicine; fap targeted; fap ... See more keywords

Design, Synthesis and Preclinical Assessment of 99mTc-iFAP for In Vivo Fibroblast Activation Protein (FAP) Imaging

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27010264

Abstract: Fibroblast activation protein (FAP) is expressed in the microenvironment of most human epithelial tumors. 68Ga-labeled FAP inhibitors based on the cyanopyrrolidine structure (FAPI) are currently used for the detection of the tumor microenvironment by PET… read more here.

Keywords: activation protein; fibroblast activation; ifap; protein fap ... See more keywords