Targeting protein folding in N‐Myc‐driven medulloblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13395
Abstract: Selective targeting of N‐Myc‐driven Sonic hedgehog (SHH) medulloblastoma has been a challenge for many years and, despite decades of research, few targeted therapy opportunities exist. Recently, Kuzuoglu‐Ozturk et al. characterized the translatome of N‐Myc‐driven medulloblastoma… read more here.
Keywords: protein folding; targeting protein; folding myc; myc driven ... See more keywords
Biophysical Approaches to Protein Folding and Disease, a satellite meeting to the IUPAB-EBSA congress
Sign Up to like & getrecommendations! Published in 2018 at "European Biophysics Journal"
DOI: 10.1007/s00249-018-1288-0
Abstract: A meeting focused on Biophysical Approaches to Protein Folding and Disease held as a satellite of the joint 19th IUPAB congress and 11th EBSA congress in Edinburgh 20–21 July 2017 (https ://arbre -mobie u.eu/ebsa-satel lite/)… read more here.
Keywords: congress; meeting; biophysical approaches; disease ... See more keywords
Exploring the Levinthal limit in protein folding
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biological Physics"
DOI: 10.1007/s10867-016-9431-6
Abstract: According to the thermodynamic hypothesis, the native state of proteins is uniquely defined by their amino acid sequence. On the other hand, according to Levinthal, the native state is just a local minimum of the… read more here.
Keywords: levinthal limit; native state; protein folding;
Channeling Nascent Proteins Towards the Native State: Role of the Ribosome and Molecular Chaperones
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.113
Abstract: Despite much progress over the last six decades, we are still far from understanding the mechanism of protein folding and aggregation in the cell. This lack of information poses tremendous challenges to progress in many… read more here.
Keywords: nascent proteins; ribosome molecular; protein folding; role ... See more keywords
Probing Protein Folding and Interaction in Live Cells using Osmotic Perturbations
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.319
Abstract: Cells rapidly change their volume in both optimal conditions and under duress, causing changes to their internal solute concentrations. Proteins are known to respond to such fluctuations in solution concentrations even faster, well before the… read more here.
Keywords: protein; probing protein; volume; live cells ... See more keywords
Protein Folding upon Binding Revealed by Molecular Dynamics Simulation
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.329
Abstract: Macromolecules frequently associate in living cells and tissues, where specific binding interactions based on dynamic conformation regulate molecular localization and activity. Despite the rapidly expanding experimental characterization of the structural proteome, the combinatorial explosion of… read more here.
Keywords: binding revealed; upon binding; folding upon; protein folding ... See more keywords
Identification and Characterization of an Inside-Out Folding Intermediate of T4 Phage Sliding Clamp.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.08.043
Abstract: Protein folding process involves formation of transiently occurring intermediates that are difficult to isolate and characterize. It is both necessary and interesting to characterize the structural conformations adopted by these intermediates, also called molten globules… read more here.
Keywords: sliding clamp; phage; protein folding; gp45 ... See more keywords
Chemical evolution of protein folding in amino acids
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Physics"
DOI: 10.1016/j.chemphys.2020.110856
Abstract: Abstract We point out why the evolution chose just twenty amino acids which further form proteins and higher cellular structures of molecules in organisms. We use the properties of the loop braid group in the… read more here.
Keywords: amino acids; evolution; chemical evolution; protein folding ... See more keywords
Effective hybrid approach for protein structure prediction in a two-dimensional Hydrophobic-Polar model
Sign Up to like & getrecommendations! Published in 2019 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2019.103397
Abstract: Hydrophobic-polar (HP) models are widely used to predict protein folding and hydrophobic interactions. Numerous optimization algorithms have been proposed to predict protein folding using the two-dimensional (2D) HP model. However, to obtain an optimal protein… read more here.
Keywords: model; prediction; protein folding; hydrophobic polar ... See more keywords
Ultrafast Protein Folding in Membrane-Mimetic Environments.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.10.031
Abstract: Proteins fold on timescales from hours to microseconds. In addition to protein size, sequence, and topology, the environment represents an equally important factor in determining folding speed. This is particularly relevant for proteins that require… read more here.
Keywords: protein; ultrafast protein; protein folding; membrane mimetic ... See more keywords
Protein folding, binding, and droplet formation in cell-like conditions.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2016.10.006
Abstract: The many bystander macromolecules in the crowded cellular environments present both steric repulsion and weak attraction to proteins undergoing folding or binding and hence impact the thermodynamic and kinetic properties of these processes. The weak… read more here.
Keywords: droplet formation; folding binding; formation cell; droplet ... See more keywords