Considerations for the Use of Polysorbates in Biopharmaceuticals
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2430-5
Abstract: PurposePolysorbates are commonly added to protein formulations and serve an important function as stabilizers. This paper reviews recent literature detailing some of the issues seen with the use of polysorbate 80 and polysorbate 20 in… read more here.
Keywords: considerations use; use polysorbates; protein formulations; strategy ... See more keywords
Stabilizers and Their Interaction with Formulation Components in Frozen and Freeze-dried Protein Formulations.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.03.003
Abstract: This review aims to provide an overview of the current knowledge on protein stabilization during freezing and freeze-drying in relation to stress conditions commonly encountered during these processes. The traditional as well as refined mechanisms… read more here.
Keywords: frozen freeze; formulation components; freeze; freeze dried ... See more keywords
Pulsed electric field preservation of liquid whey protein formulations – Influence of process parameters, pH, and protein content on the inactivation of Listeria innocua and the retention of bioactive ingredients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Food Engineering"
DOI: 10.1016/j.jfoodeng.2018.09.003
Abstract: Abstract A gentle preservation concept for heat sensitive protein formulations based on the application of pulsed electric fields (PEF) was developed. The inactivation of L. innocua in 2 and 10% whey protein isolate (WPI) formulations… read more here.
Keywords: preservation; inactivation; electric field; pulsed electric ... See more keywords
Role of Buffers in Protein Formulations.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2016.11.014
Abstract: Buffers comprise an integral component of protein formulations. Not only do they function to regulate shifts in pH, they also can stabilize proteins by a variety of mechanisms. The ability of buffers to stabilize therapeutic… read more here.
Keywords: buffers protein; stability; role buffers; protein formulations ... See more keywords
Additivity of Transfer Free Energies Enables the Description of Complex Protein Formulations in Implicit Solvent Molecular Dynamics Simulations.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.5c00169
Abstract: A complex 3D structure and the surrounding environment determine the function and stability of a protein. Various osmolytes can be added to a protein drug formulation to stabilize the native protein structure by preventing unfolding… read more here.
Keywords: free energies; transfer free; protein; molecular dynamics ... See more keywords
In-situ biophysical characterization of high-concentration protein formulations using wNMR
Sign Up to like & getrecommendations! Published in 2024 at "mAbs"
DOI: 10.1080/19420862.2024.2304624
Abstract: ABSTRACT High-concentration protein formulation is of paramount importance in patient-centric drug product development, but it also presents challenges due to the potential for enhanced aggregation and increased viscosity. The analysis of critical quality attributes often… read more here.
Keywords: concentration protein; situ biophysical; high concentration; concentration ... See more keywords
Protein Formulations Containing Polysorbates: Are Metal Chelators Needed at All?
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DOI: 10.3390/antiox9050441
Abstract: Proteins are prone to post-translational modifications at specific sites, which can affect their physicochemical properties, and consequently also their safety and efficacy. Sources of post-translational modifications include oxygen and reactive oxygen species. Additionally, catalytic amounts… read more here.
Keywords: addition; formulations containing; post translational; dtpa addition ... See more keywords
Hydroxylpropyl-β-cyclodextrin as Potential Excipient to Prevent Stress-Induced Aggregation in Liquid Protein Formulations
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165094
Abstract: Due to the growing demand for patient-friendly subcutaneous dosage forms, the ability to increasing protein solubility and stability in formulations to deliver on the required high protein concentrations is crucial. A common approach to ensure… read more here.
Keywords: liquid protein; hydroxylpropyl cyclodextrin; stability; protein formulations ... See more keywords