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Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2430-5
Abstract: PurposePolysorbates are commonly added to protein formulations and serve an important function as stabilizers. This paper reviews recent literature detailing some of the issues seen with the use of polysorbate 80 and polysorbate 20 in…
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Keywords:
considerations use;
use polysorbates;
protein formulations;
strategy ... See more keywords
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Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.03.003
Abstract: This review aims to provide an overview of the current knowledge on protein stabilization during freezing and freeze-drying in relation to stress conditions commonly encountered during these processes. The traditional as well as refined mechanisms…
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Keywords:
frozen freeze;
formulation components;
freeze;
freeze dried ... See more keywords
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Published in 2019 at "Journal of Food Engineering"
DOI: 10.1016/j.jfoodeng.2018.09.003
Abstract: Abstract A gentle preservation concept for heat sensitive protein formulations based on the application of pulsed electric fields (PEF) was developed. The inactivation of L. innocua in 2 and 10% whey protein isolate (WPI) formulations…
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Keywords:
preservation;
inactivation;
electric field;
pulsed electric ... See more keywords
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Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2016.11.014
Abstract: Buffers comprise an integral component of protein formulations. Not only do they function to regulate shifts in pH, they also can stabilize proteins by a variety of mechanisms. The ability of buffers to stabilize therapeutic…
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Keywords:
buffers protein;
stability;
role buffers;
protein formulations ... See more keywords
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Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9050441
Abstract: Proteins are prone to post-translational modifications at specific sites, which can affect their physicochemical properties, and consequently also their safety and efficacy. Sources of post-translational modifications include oxygen and reactive oxygen species. Additionally, catalytic amounts…
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Keywords:
addition;
formulations containing;
post translational;
dtpa addition ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165094
Abstract: Due to the growing demand for patient-friendly subcutaneous dosage forms, the ability to increasing protein solubility and stability in formulations to deliver on the required high protein concentrations is crucial. A common approach to ensure…
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Keywords:
liquid protein;
hydroxylpropyl cyclodextrin;
stability;
protein formulations ... See more keywords