Human Amylin in the Presence of SARS-COV-2 Protein Fragments.
Sign Up to like & getrecommendations! Published in 2023 at "ACS omega"
DOI: 10.1021/acsomega.3c00621
Abstract: COVID-19 can lead to the onset of type-II diabetes, which is associated with the aggregation of islet amyloid polypeptides, also called amylin. Using molecular dynamics simulations, we investigate how the equilibrium between amylin monomers in… read more here.
Keywords: cov protein; protein fragments; presence sars; sars cov ... See more keywords
Mapping functional regions of essential bacterial proteins with dominant-negative protein fragments
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.01.04.474984
Abstract: Massively-parallel measurements of dominant negative inhibition by protein fragments have been used to map protein interaction sites and discover peptide inhibitors. However, the underlying principles governing fragment-based inhibition have thus far remained unclear. Here, we… read more here.
Keywords: inhibition; protein fragments; inhibitory activity; dominant negative ... See more keywords
Peptide binding affinity redistributes preassembled repeat protein fragments
Sign Up to like & getrecommendations! Published in 2019 at "Biological Chemistry"
DOI: 10.1515/hsz-2018-0355
Abstract: Abstract Designed armadillo repeat proteins (dArmRPs) are modular peptide binders composed of N- and C-terminal capping repeats Y and A and a variable number of internal modules M that each specifically recognize two amino acids… read more here.
Keywords: protein; peptide; affinity; target peptide ... See more keywords
Physiological State Dictates the Proteasomal-mediated Purging of Misfolded Protein Fragments.
Sign Up to like & getrecommendations! Published in 2019 at "Protein and peptide letters"
DOI: 10.2174/0929866526666191026111951
Abstract: A pivotal feature that underlies the development of neurodegeneration is the accumulation of protein aggregates. In response, eukaryotic cells have evolved sophisticated quality control mechanisms to identify, repair and/or eliminate the misfolded abnormal proteins. Chaperones… read more here.
Keywords: protein; dictates proteasomal; proteasomal mediated; state dictates ... See more keywords