Band 3 protein function and oxidative stress in erythrocytes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30322
Abstract: Band 3 protein (B3p), anion transporter, allows the HCO3 −/Cl− exchange across plasma membrane and plays an important role for erythrocytes homeostasis. In addition, B3p is linked to proteins cytoskeleton, thus contributing to cell shape… read more here.
Keywords: band protein; protein function; stress; stress erythrocytes ... See more keywords
Protein Function Prediction: From Traditional Classifier to Deep Learning
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201900119
Abstract: Deep learning demonstrates greater competence over traditional machine learning techniques for many tasks. In last several years, deep learning has been applied to protein function prediction and a series of good achievements has been obtained.… read more here.
Keywords: protein function; deep learning; function prediction;
Chimeric dihydrofolate reductases display properties of modularity and biophysical diversity
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3646
Abstract: While reverse genetics and functional genomics have long affirmed the role of individual mutations in determining protein function, there have been fewer studies addressing how large‐scale changes in protein sequences, such as in entire modular… read more here.
Keywords: dihydrofolate; genetics; protein function; chimeric dihydrofolate ... See more keywords
Structural Stringency of Cholesterol for Membrane Protein Function Utilizing Stereoisomers as Novel Tools: A Review.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6875-6_3
Abstract: Cholesterol is an important lipid in the context of membrane protein function. The function of a number of membrane proteins, including G protein-coupled receptors (GPCRs) and ion channels, has been shown to be dependent on… read more here.
Keywords: protein function; membrane; membrane protein; cholesterol ... See more keywords
Membranes Matter: Predicting Drug Toxicity
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2804
Abstract: It remains a challenge to predict whether a new drug candidate will have undesirable side effects. Many biologically active molecules, including drugs and drug-leads, are amphiphiles that partition into lipid bilayers, which will tend to… read more here.
Keywords: drug; protein function; toxicity; bilayer ... See more keywords
PFmulDL: a novel strategy enabling multi-class and multi-label protein function annotation by integrating diverse deep learning methods.
Sign Up to like & getrecommendations! Published in 2022 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2022.105465
Abstract: Bioinformatic annotation of protein function is essential but extremely sophisticated, which asks for extensive efforts to develop effective prediction method. However, the existing methods tend to amplify the representativeness of the families with large number… read more here.
Keywords: function annotation; prediction; function; protein function ... See more keywords
Protein function machinery: from basic structural units to modulation of activity.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2016.10.021
Abstract: Contemporary protein structure is a result of the trade off between the laws of physics and the evolutionary selection. The polymer nature of proteins played a decisive role in establishing the basic structural and functional… read more here.
Keywords: protein; function machinery; basic structural; protein function ... See more keywords
Regulating Protein Function by Delayed Folding.
Sign Up to like & getrecommendations! Published in 2018 at "Structure"
DOI: 10.1016/j.str.2018.04.011
Abstract: In this issue of Structure, Tsirigotaki et al. (2018) use bioinformatics and biophysical tools to demonstrate that many secreted proteins form long-lived, loosely packed folding intermediates. This delayed folding correlates with elevated disorder and reduced hydrophobicity… read more here.
Keywords: protein function; function delayed; delayed folding; regulating protein ... See more keywords
Methods of reconstitution to investigate membrane protein function.
Sign Up to like & getrecommendations! Published in 2018 at "Methods"
DOI: 10.1016/j.ymeth.2018.02.012
Abstract: Membrane proteins are notoriously difficult to investigate in isolation. The focus of this chapter is the key step following extraction and purification of membrane proteins; namely reconstitution. The process of reconstitution re-inserts proteins into a… read more here.
Keywords: membrane proteins; methods reconstitution; reconstitution; protein function ... See more keywords
DeepText2GO: Improving large-scale protein function prediction with deep semantic text representation.
Sign Up to like & getrecommendations! Published in 2018 at "Methods"
DOI: 10.1016/j.ymeth.2018.05.026
Abstract: As of April 2018, UniProtKB has collected more than 115 million protein sequences. Less than 0.15% of these proteins, however, have been associated with experimental GO annotations. As such, the use of automatic protein function… read more here.
Keywords: protein; deep semantic; protein function; function prediction ... See more keywords
Metabolic Labeling-Based Chemoproteomics Establishes Choline Metabolites as Protein Function Modulators.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00400
Abstract: Choline is an essential nutrient for mammalian cells. Our understanding of the cellular functions of choline and its metabolites, independent of their roles as choline lipid metabolism intermediates, remains limited. In addition to fundamental cellular… read more here.
Keywords: metabolic labeling; choline metabolites; physiology; biology ... See more keywords