Cleavage of the Babuvirus Movement Protein B4 into Functional Peptides Capable of Host Factor Conjugation is Required for Virulence
Sign Up to like & getrecommendations! Published in 2019 at "Virologica Sinica"
DOI: 10.1007/s12250-019-00094-4
Abstract: AbstractBanana bunchy top virus (BBTV) poses a serious danger to banana crops worldwide. BBTV-encoded protein B4 is a determinant of pathogenicity. However, the relevant molecular mechanisms underlying its effects remain unknown. In this study, we… read more here.
Keywords: protein functional; cleavage babuvirus; host; babuvirus movement ... See more keywords
Towards omics-based predictions of planktonic functional composition from environmental data
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24547-1
Abstract: Marine microbes play a crucial role in climate regulation, biogeochemical cycles, and trophic networks. Unprecedented amounts of data on planktonic communities were recently collected, sparking a need for innovative data-driven methodologies to quantify and predict… read more here.
Keywords: towards omics; protein functional; functional clusters; composition environmental ... See more keywords
Exploring Approaches for Detecting Protein Functional Similarity within an Orthology-based Framework
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DOI: 10.1038/s41598-017-00465-5
Abstract: Protein functional similarity based on gene ontology (GO) annotations serves as a powerful tool when comparing proteins on a functional level in applications such as protein-protein interaction prediction, gene prioritization, and disease gene discovery. Functional similarity… read more here.
Keywords: similarity; functional similarity; exploring approaches; protein functional ... See more keywords
Effect of sequence padding on the performance of deep learning models in archaeal protein functional prediction
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DOI: 10.1038/s41598-020-71450-8
Abstract: The use of raw amino acid sequences as input for deep learning models for protein functional prediction has gained popularity in recent years. This scheme obliges to manage proteins with different lengths, while deep learning… read more here.
Keywords: learning models; deep learning; protein functional; effect ... See more keywords
Identification of key residues in protein functional movements by using molecular dynamics simulations combined with a perturbation-response scanning method
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Physics B"
DOI: 10.1088/1674-1056/abf12f
Abstract: The realization of protein functional movement is usually accompanied by specific conformational changes, and there exist some key residues that mediate and control the functional motions of proteins in the allosteric process. In the present… read more here.
Keywords: response scanning; perturbation response; protein functional; scanning method ... See more keywords