Parallel study on protein O-GlcNAcylation in prostate cancer cell with a sensitive microarray biochip.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2018.08.004
Abstract: Although a variety of approaches have been developed to analyze protein O-GlcNAcylation, efficient investigations on O-GlcNAcylation of proteins of interest in high-throughput manner are still in high demand to further explore its functionality. In this… read more here.
Keywords: prostate cancer; glcnacylation; protein glcnacylation; cancer cell ... See more keywords
O-GlcNAc Regulation of Autophagy and α-synuclein Homeostasis; Implications for Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.282
Abstract: Post-translational modification on protein Ser/Thr residues by O-linked attachment of s-N-acetyl-glucosamine (O-GlcNAcylation) is a key mechanism integrating redox signaling, metabolism and stress responses. One of the most common neurodegenerative diseases that exhibit aberrant redox signaling,… read more here.
Keywords: glcnac regulation; regulation autophagy; glcnacylation; protein glcnacylation ... See more keywords
Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105467
Abstract: Cardiovascular diseases (CVDs) are the leading cause of death globally. While the major focus of pharmacological and non-pharmacological interventions has been on targeting disease pathophysiology and limiting predisposing factors, our understanding of the cellular and… read more here.
Keywords: glcnacylation cardiovascular; therapeutic targets; emerging roles; glcnacylation ... See more keywords
Global and Site-Specific Analysis Revealing Unexpected and Extensive Protein S-GlcNAcylation in Human Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.6b05064
Abstract: Protein glycosylation is highly diverse and essential for mammalian cell survival. Heterogeneous glycans may be bound to different amino acid residues, forming multiple types of protein glycosylation. In this work, unexpected protein S-GlcNAcylation on cysteine… read more here.
Keywords: global site; site specific; glcnacylation; specific analysis ... See more keywords
Deciphering the Functions of Protein O-GlcNAcylation with Chemistry.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b01065
Abstract: O-GlcNAcylation is the modification of serine and threonine residues with β-N-acetylglucosamine (O-GlcNAc) on intracellular proteins. This dynamic modification is attached by O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA) and is a critical regulator of… read more here.
Keywords: deciphering functions; chemistry; glcnacylation; protein glcnacylation ... See more keywords
Altered protein O-GlcNAcylation in placentas from mothers with diabetes causes aberrant endocytosis in placental trophoblast cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00045-8
Abstract: Women with pre-existing diabetes have an increased risk of poor pregnancy outcomes, including disordered fetal growth, caused by changes to placental function. Here we investigate the possibility that the hexosamine biosynthetic pathway, which utilises cellular… read more here.
Keywords: altered protein; glcnacylation; placentas mothers; endocytosis ... See more keywords
Recent development of analytical methods for disease-specific protein O-GlcNAcylation
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra07184c
Abstract: The enzymatic modification of protein serine or threonine residues by N-acetylglucosamine, namely O-GlcNAcylation, is a ubiquitous post-translational modification that frequently occurs in the nucleus and cytoplasm. O-GlcNAcylation is dynamically regulated by two enzymes, O-GlcNAc transferase… read more here.
Keywords: analytical methods; disease; protein glcnacylation; recent development ... See more keywords
Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation
Sign Up to like & getrecommendations! Published in 2017 at "JCI Insight"
DOI: 10.1172/jci.insight.96184
Abstract: Cardiac hypertrophic remodeling during chronic hemodynamic stress is associated with a switch in preferred energy substrate from fatty acids to glucose, usually considered to be energetically favorable. The mechanistic interrelationship between altered energy metabolism, remodeling,… read more here.
Keywords: reprograms cardiac; metabolism; fatty acid; stress ... See more keywords
Protein O-GlcNAcylation Is Essential for the Maintenance of Renal Energy Homeostasis and Function via Lipolysis during Fasting and Diabetes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2018090950
Abstract: BACKGROUND Energy metabolism in proximal tubular epithelial cells (PTECs) is unique, because ATP production largely depends on lipolysis in both the fed and fasting states. Furthermore, disruption of renal lipolysis is involved in the pathogenesis… read more here.
Keywords: lipolysis; glcnacylation; energy; renal lipolysis ... See more keywords
Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Life science alliance"
DOI: 10.26508/lsa.202201385
Abstract: Protein O-GlcNAcylation is a dynamic, nutrient-sensitive mono-glycosylation deposited on numerous nucleo-cytoplasmic and mitochondrial proteins, including transcription factors, epigenetic regulators, and histones. However, the role of protein O-GlcNAcylation on epigenome regulation in response to nutrient perturbations… read more here.
Keywords: glcnac; nutrient sensitive; glcnacylation; embryonic neurogenesis ... See more keywords
Changes in Protein O-GlcNAcylation During Mouse Epididymal Sperm Maturation
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00060
Abstract: After leaving the testis, sperm undergo two sequential maturational processes before acquiring fertilizing capacity: sperm maturation in the male epididymis, and sperm capacitation in the female reproductive tract. During their transit through the epididymis, sperm… read more here.
Keywords: post translational; changes protein; glcnacylation; sperm maturation ... See more keywords