On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.29925
Abstract: The B-cell CLL 2-associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence… read more here.
Keywords: protein homeostasis; bag3; role; bag ... See more keywords
The interplay between aging‐associated loss of protein homeostasis and extracellular vesicles in neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24526
Abstract: The finding of an effective cure or treatment for neurodegenerative diseases is one of the biggest challenges for this century. Although these diseases show different clinical manifestations, the presence of toxic protein aggregates in the… read more here.
Keywords: protein; extracellular vesicles; protein homeostasis; loss protein ... See more keywords
Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3639
Abstract: The effect of mutations in individual proteins on protein homeostasis, or “proteostasis,” can in principle depend on the mutations' effects on the thermodynamics or kinetics of folding, or both. Here, we explore this issue using… read more here.
Keywords: protein; versus thermodynamic; protein homeostasis; time ... See more keywords
Adenosine triphosphate energy‐independently controls protein homeostasis with unique structure and diverse mechanisms
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4079
Abstract: Proteins function in the crowded cellular environments with high salt concentrations, thus facing tremendous challenges of misfolding/aggregation which represents a pathological hallmark of aging and an increasing spectrum of human diseases. Recently, intrinsically disordered regions… read more here.
Keywords: aggregation; energy; protein homeostasis; diverse mechanisms ... See more keywords
Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2D
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.10.002
Abstract: Upregulations of neuronal nitric oxide synthase (nNOS) in the rodent brain have been associated with neuronal aging. To address underlying mechanisms we generated SH-SY5Y neuronal cells constitutively expressing nNOS at a level similar to mouse… read more here.
Keywords: homeostasis; protein homeostasis; cell cycle; oxide contributes ... See more keywords
Small-Molecule Modulation of Protein Homeostasis.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.7b00077
Abstract: Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics.… read more here.
Keywords: protein; molecule modulation; protein homeostasis; control ... See more keywords
The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.88
Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by the selective degeneration of motor neurons (MNs) and their target muscles. Misfolded proteins which often form intracellular aggregates are a pathological hallmark of ALS. Disruption of the functional… read more here.
Keywords: homeostasis; e102q sigr1; protein homeostasis; rna binding ... See more keywords
Actin dynamics in protein homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20210848
Abstract: Abstract Cell homeostasis is maintained in all organisms by the constant adjustment of cell constituents and organisation to account for environmental context. Fine-tuning of the optimal balance of proteins for the conditions, or protein homeostasis,… read more here.
Keywords: actin dynamics; cell; protein homeostasis; homeostasis actin ... See more keywords
The discovery and consequences of the central role of the nervous system in the control of protein homeostasis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurogenetics"
DOI: 10.1080/01677063.2020.1771333
Abstract: Abstract Organisms function despite wide fluctuations in their environment through the maintenance of homeostasis. At the cellular level, the maintenance of proteins as functional entities at target expression levels is called protein homeostasis (or proteostasis).… read more here.
Keywords: protein homeostasis; nervous system; control; discovery consequences ... See more keywords
Protein Homeostasis Database: protein quality control in E.coli
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz628
Abstract: MOTIVATION In vivo protein folding is governed by molecular chaperones, that escort proteins from their translational birth to their proteolytic degradation. In E. coli the main classes of chaperones that interact with the nascent chain… read more here.
Keywords: protein homeostasis; database protein; protein quality; homeostasis database ... See more keywords
Protein homeostasis, regulation of energy production and activation of DNA damage-repair pathways are involved in the heat stress response of Pseudogymnoascus spp.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental microbiology"
DOI: 10.1111/1462-2920.15776
Abstract: Proteome changes can be used as an instrument to measure the effects of climate change, predict the possible future state of an ecosystem and the direction in which is headed. In this study, proteomic and… read more here.
Keywords: protein; protein homeostasis; regulation energy; heat stress ... See more keywords