Mitochondrial protein import machinery conveys stress signals to the cytosol and beyond
Sign Up to like & getrecommendations! Published in 2023 at "BioEssays"
DOI: 10.1002/bies.202200160
Abstract: Mitochondria hold diverse and pivotal roles in fundamental processes that govern cell survival, differentiation, and death, in addition to organismal growth, maintenance, and aging. The mitochondrial protein import system is a major contributor to mitochondrial… read more here.
Keywords: machinery conveys; protein import; mitochondrial protein; import machinery ... See more keywords
Peroxisomal Membrane and Matrix Protein Import Using a Semi-Intact Mammalian Cell System.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6937-1_20
Abstract: Peroxisomes are essential intracellular organelles that catalyze a number of essential metabolic pathways including β-oxidation of very long chain fatty acids, synthesis of plasmalogen, bile acids, and generation and degradation of hydrogen peroxide. These peroxisomal… read more here.
Keywords: protein import; system; import; semi intact ... See more keywords
Partial dispensability of Djp1's J domain in peroxisomal protein import in Saccharomyces cerevisiae results from genetic redundancy with another class II J protein, Caj1
Sign Up to like & getrecommendations! Published in 2017 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-017-0779-8
Abstract: J proteins are obligate co-chaperones of Hsp70s. Via their signature J domain, all J proteins interact with their partner Hsp70s and stimulate their weak ATPase activity, which is vital for Hsp70 functions. The dependency of… read more here.
Keywords: protein; protein import; djp1; peroxisomal protein ... See more keywords
Massive Protein Import into the Early-Evolutionary-Stage Photosynthetic Organelle of the Amoeba Paulinella chromatophora
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.08.010
Abstract: The endosymbiotic acquisition of mitochondria and plastids more than 1 Ga ago profoundly impacted eukaryote evolution. At the heart of understanding organelle evolution is the re-arrangement of the endosymbiont proteome into a host-controlled organellar proteome.… read more here.
Keywords: protein import; paulinella chromatophora; amoeba paulinella;
Evolution: Protein Import in a Nascent Photosynthetic Organelle
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.08.013
Abstract: An amoeba named Paulinella harbours 'chromatophores', cyanobacterium-derived photosynthetic bodies that evolved independent of plastids. Proteomics has shown that hundreds of nucleus-encoded proteins are targeted to the chromatophore, revealing the host cell's contributions to its recently… read more here.
Keywords: protein import; nascent photosynthetic; photosynthetic organelle; biology ... See more keywords
Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2018.11.003
Abstract: Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the… read more here.
Keywords: targeting glycosomal; protein import; come sweet; sweet death ... See more keywords
Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2493
Abstract: Tim17 and Tim23 are the main subunits of the TIM23 complex, one of the two major essential mitochondrial inner-membrane protein translocon machineries (TIMs). No chemical probes that specifically inhibit TIM23-dependent protein import were known to… read more here.
Keywords: protein; protein import; tim23 dependent; tim23 complex ... See more keywords
Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28272-1
Abstract: Sustained mitochondrial fitness relies on coordinated biogenesis and clearance. Both processes are regulated by constant targeting of proteins into the organelle. Thus, mitochondrial protein import sets the pace for mitochondrial abundance and function. However, our… read more here.
Keywords: mitochondrial protein; novo serine; serine biosynthesis; protein import ... See more keywords
Mitochondrial diseases caused by dysfunctional mitochondrial protein import.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society transactions"
DOI: 10.1042/bst20180239
Abstract: Mitochondria are essential organelles which perform complex and varied functions within eukaryotic cells. Maintenance of mitochondrial health and functionality is thus a key cellular priority and relies on the organelle's extensive proteome. The mitochondrial proteome… read more here.
Keywords: mitochondrial protein; protein import; mitochondrial diseases; diseases caused ... See more keywords
Structural components involved in plastid protein import.
Sign Up to like & getrecommendations! Published in 2018 at "Essays in biochemistry"
DOI: 10.1042/ebc20170093
Abstract: Import of preproteins into chloroplasts is an essential process, requiring two major multisubunit protein complexes that are embedded in the outer and inner chloroplast envelope membrane. Both the translocon of the outer chloroplast membrane (Toc),… read more here.
Keywords: plastid protein; protein import; structural components; import ... See more keywords
Coexpressed subunits of dual genetic origin define a conserved supercomplex mediating essential protein import into chloroplasts
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2014294117
Abstract: Significance Chloroplasts are of vital importance in photosynthetic eukaryotic organisms. Like mitochondria, they contain their own genomes. Nevertheless, most chloroplast proteins are encoded by nuclear genes, translated in the cytosol, and must cross the chloroplast… read more here.
Keywords: protein; coexpressed subunits; protein import; chloroplast protein ... See more keywords